PXD027173

PXD027173 is an original dataset announced via ProteomeXchange.

Title	Proteomic changes linked to the limbic stage of AD
Description	Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia worldwide. In AD, neurodegeneration spreads throughout the brain cortex in a gradual and predictable pattern, causing progressive memory decline and cognitive impairment. Here, we conducted proteomic, acetylomic and phosphoproteomic analyses of human postmortem tissue samples from AD (Braak stage III-IV) and control brains, covering all anatomical areas affected during the limbic stage of the disease (total hippocampus, CA1, entorhinal and perirhinal cortices). A total of 58 tissues were analyzed by nanoLC-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2021-12-30
AnnouncementXML	Submission_2021-12-30_14:28:45.754.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Melinda Rezeli
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-07 21:38:39	ID requested
⏵ 1	2021-12-30 14:28:46	announced

Vel, á, squez E, Szeitz B, Gil J, Rodriguez J, Palkovits M, Renner É, Hortob, á, gyi T, D, ö, me P, Nogueira FC, Marko-Varga G, Domont GB, Rezeli M, Topological Dissection of Proteomic Changes Linked to the Limbic Stage of Alzheimer's Disease. Front Immunol, 12():750665(2021) [pubmed]

submitter keyword: Alzheimer's disease, limbic stage, proteomics, phosphoproteomics, neuroinflammation

Gyorgy Marko-Varga
contact affiliation	Department of Biomedical Engineering, Lund University, Lund, Sweden
contact email	gyorgy.marko-varga@bme.lth.se
lab head
Melinda Rezeli
contact affiliation	Lund University
contact email	melinda.rezeli@bme.lth.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD027173

PRIDE project URI

• PRIDE
  1. PXD027173
     1. Label: PRIDE project
     2. Name: Proteomic changes linked to the limbic stage of AD