PXD027164

PXD027164 is an original dataset announced via ProteomeXchange.

Title	Global protein responses of multi-drug resistant plasmid containing Escherichia coli to beta-lactams and ciprofloxacin.
Description	Our study aimed to analyse the responses of the clonal ST131 strain, containing the ESBL and multi-drug resistance plasmid under different beta-lactam and ciprofloxacin antibiotic stress in comparison with no antibiotic stresses in order to identify the specific response of a MDR plasmid to the specific antibiotic and the potential interaction between the plasmid and the host bacteria under different stresses. The aim was to understand how the plasmid and bacterial host proteins are influenced by the different antibiotic stresses. By analysing these factors systematically we aimed to identify the pathways and core or antibiotic specific responses of the bacteria. Using proteomics we provide an unbiased protein map of a pathogen with a MDR plasmid under antibiotic stress and compare it with the same bacteria in the absence of the stress.
HostingRepository	PRIDE
AnnounceDate	2022-10-12
AnnouncementXML	Submission_2022-10-12_08:48:17.776.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	JamesCarolan
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-07 07:04:46	ID requested
⏵ 1	2022-10-12 08:48:18	announced

Dataset with its publication pending

submitter keyword: antibiotics, proteomics, E. coli,anti microbial resistance

JamesCarolan
contact affiliation	Maynooth University, Ireland
contact email	james.carolan@mu.ie
lab head
JamesCarolan
contact affiliation	Biology
contact email	james.carolan@nuim.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD027164

PRIDE project URI

• PRIDE
  1. PXD027164
     1. Label: PRIDE project
     2. Name: Global protein responses of multi-drug resistant plasmid containing Escherichia coli to beta-lactams and ciprofloxacin.