PXD027142

PXD027142 is an original dataset announced via ProteomeXchange.

Title	Renal cell-derived extracellular vesicles as a modulator of tubuloid functional maturation
Description	Tubuloids are adult stem cell-based kidney organoids with promising application in kidney disease modelling and drug screening. However, tubuloids still present limited transepithelial transport capacity, which is essential for the kidney’s function. The extracellular vesicles (EVs) are cell-derived vesicular structures known to regulate several cellular processes, including development and maturation. This study explores the potential of EVs derived from renal cells to support tubuloid functional maturation by increasing the levels of organic anion transport 1 (OAT1), a protein involved in renal waste handling.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_05:55:49.859.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Franziska Voellmy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-07 02:16:17	ID requested
⏵ 1	2022-08-12 05:55:50	announced

Lindoso RS, Yousef Yengej FA, Voellmy F, Altelaar M, Manche, ñ, o Juncosa E, Tsikari T, Ammerlaan CME, Van Balkom BWM, Rookmaaker MB, Verhaar MC, Masereeuw R, Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids. J Nanobiotechnology, 20(1):326(2022) [pubmed]

submitter keyword: extracellular vesicles, tubuloids, organic ion transporter 1, kidney organoids, proteomics

Rosalinde Masereeuw
contact affiliation	Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands
contact email	r.masereeuw@uu.nl
lab head
Franziska Voellmy
contact affiliation	Utrecht University
contact email	franziska.voellmy@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD027142

PRIDE project URI

• PRIDE
  1. PXD027142
     1. Label: PRIDE project
     2. Name: Renal cell-derived extracellular vesicles as a modulator of tubuloid functional maturation