PXD027111

PXD027111 is an original dataset announced via ProteomeXchange.

Title	The plasma proteins from human multiple myeloma was enriched by lectin AANL6 and identified by LC-MS/MS
Description	Lectin is widely used to enrich glycoconjugates carrying glycans and to identify the abnormal glycosylated proteins in tumor with mass spectrometry, which is a useful tool for cancer diagnosis and prognosis monitoring. In our previously reported, we identified a novel lectin AANL from Agrocybe aegerita that has a higher affinity than other lectins when binding with GlcNAc, and the lectin AANL has been used for early diagnosis of non-small cell lung cancer. Subsequently, AANL6, a mutant of AANL, is cloned and purified, and has higher affinity to terminal GlcNAc than AANL. Therefore, in this study, we used the lectin AANL6 for enrichment of glycosylated peoteins from MM, and identified with quantitative proteomics, in order to find a potential sensitive biomarker for MM diagnosis.
HostingRepository	PRIDE
AnnounceDate	2024-05-22
AnnouncementXML	Submission_2024-05-22_01:48:22.337.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanxia Jin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-05 08:55:53	ID requested
⏵ 1	2024-05-22 01:48:23	announced

Jin Y, Liang Y, Su Y, Hui L, Liu H, Ding L, Zhou F, Identification of novel combined biomarkers in the diagnosis of multiple myeloma. Hematology, 26(1):964-969(2021) [pubmed]

10.1080/16078454.2021.2003065;

submitter keyword: Lectin AANL6, MM, Human, Plasma, LC-MS/MS

Yanxia Jin
contact affiliation	Wuhan University
contact email	jinyanxia@hbnu.edu.cn
lab head
Yanxia Jin
contact affiliation	Hubei Normal University
contact email	jinyanxia@hbnu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027111
     1. Label: PRIDE project
     2. Name: The plasma proteins from human multiple myeloma was enriched by lectin AANL6 and identified by LC-MS/MS