PXD027093
PXD027093 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Spatially region resolved proteomic map reveals extracellular matrix regulates epidermal growth and function as epidermal stem cell niche |
| Description | Spatial proteins expression is critical to identify exactly protein localization and function in tissues. By combining decellularization, laser-capture microdissection, and mass spectrometry, six different partitioned proteins among skin layers of stratum corneum (SC), granular-spinous (GS), basal layer (BL), BM, superficial dermis (SD), and deep dermis (DD) were isolated, enriched and for the first time, a stratified and developmental lineage proteome map of human skin has been revealed spatially. Especially, we found TGFβ induced (TGFBI), an ECM glycoprotein, in the BM that enhances the proliferation of EpSCs and promotes the process of wound healing. Most interestingly, TGFBI shows the potential for treating secondary syphilis patients, which may benefit clinical practice. |
| HostingRepository | iProX |
| AnnounceDate | 2021-07-05 |
| AnnouncementXML | Submission_2022-12-18_19:01:56.391.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jie Ma |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue; iodoacetamide derivatized residue; monohydroxylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-07-04 23:16:21 | ID requested | |
| 1 | 2022-04-07 04:51:09 | announced | |
| ⏵ 2 | 2022-12-18 19:01:57 | announced | 2022-12-19: Update publication information. |
Publication List
| Li J, Ma J, Zhang Q, Gong H, Gao D, Wang Y, Li B, Li X, Zheng H, Wu Z, Zhu Y, Leng L, Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth. Nat Commun, 13(1):4012(2022) [pubmed] |
Keyword List
| submitter keyword: Spatial proteomic, Extracellular matrix, Epidermal stem cell, Wound healing |
Contact List
| Yunping Zhu | |
|---|---|
| contact affiliation | National Center for Protein Sciences (Beijing) |
| contact email | zhuyunping@gmail.com |
| lab head | |
| Jie Ma | |
| contact affiliation | National Center for Protein Sciences (Beijing) |
| contact email | majie729@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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