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PXD027044

PXD027044 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titleproteomic analysis of leukocytes upon Plekhm1-KO
DescriptionLeukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusion and secretion of intracellular vesicles. Here, we performed TMT-based quantitative proteomics to investigate the proteome of BMM-derived leucocytesfrom mice lacking Plekhm1 compared to wild-type animals, which have been transplanted withBCR-ABL1-expressing bone marrow cells.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:19:29.979.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGeorg Tascher
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-07-01 07:56:45ID requested
12023-01-16 03:59:52announced
22023-11-14 07:19:32announced2023-11-14: Updated project metadata.
Publication List
Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, Pereira RS, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann LM, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, M, ü, nch C, Dikic I, Krause DS, Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv, 7(7):1190-1203(2023) [pubmed]
Keyword List
submitter keyword: SPS-MS3, TMT,mesenchymal stromal cells, mouse, Orbitrap Lumos
Contact List
Daniela Krause
contact affiliationGoethe-Universität Frankfurt, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, Frankfurt am Main, GERMANY
contact emailKrause@gsh.uni-frankfurt.de
lab head
Georg Tascher
contact affiliationInstitute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany
contact emailtascher@med.uni-frankfurt.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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