PXD027044 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | proteomic analysis of leukocytes upon Plekhm1-KO |
Description | Leukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusion and secretion of intracellular vesicles. Here, we performed TMT-based quantitative proteomics to investigate the proteome of BMM-derived leucocytesfrom mice lacking Plekhm1 compared to wild-type animals, which have been transplanted withBCR-ABL1-expressing bone marrow cells. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:19:29.979.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Georg Tascher |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-01 07:56:45 | ID requested | |
1 | 2023-01-16 03:59:52 | announced | |
⏵ 2 | 2023-11-14 07:19:32 | announced | 2023-11-14: Updated project metadata. |
Publication List
Karantanou C, Minciacchi VR, Kumar R, Zanetti C, Bravo J, Pereira RS, Tascher G, Tertel T, Covarrubias-Pinto A, Bankov K, Pfeffermann LM, Bonig H, Divieti-Pajevic P, McEwan DG, Giebel B, M, ü, nch C, Dikic I, Krause DS, Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv, 7(7):1190-1203(2023) [pubmed] |
Keyword List
submitter keyword: SPS-MS3, TMT,mesenchymal stromal cells, mouse, Orbitrap Lumos |
Contact List
Daniela Krause |
contact affiliation | Goethe-Universität Frankfurt, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, Frankfurt am Main, GERMANY |
contact email | Krause@gsh.uni-frankfurt.de |
lab head | |
Georg Tascher |
contact affiliation | Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany |
contact email | tascher@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD027044 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027044
- Label: PRIDE project
- Name: proteomic analysis of leukocytes upon Plekhm1-KO