PXD027029

PXD027029 is an original dataset announced via ProteomeXchange.

Title	mGBP2 interacting proteins during Toxoplasma gondii infection
Description	Guanylate binding proteins (GBPs) are a family of large interferon-inducible GTPases that execute essential host defense activities against a wide variety of intracellular microbial pathogens. Toxoplasma gondii is an invasive intracellular apicomplexan protozoan parasite of global importance. Murine GBPs (mGBPs) recognize T. gondii PVs and assemble into supramolecular mGBP homo- and heterocomplexes that are required for the disruption of the membrane of PVs eventually resulting in the cell-autonomous immune control of vacuole-resident pathogens. Here, in order to unravel mGBP2 functions, we characterized mGBP2 protein interactions partners in cells with and without Toxoplasma gondii infection by an AP-MS approach.
HostingRepository	PRIDE
AnnounceDate	2024-10-31
AnnouncementXML	Submission_2024-10-31_10:20:34.588.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Toxoplasma gondii; NCBI TaxID: 5811; scientific name: Toxoplasma gondii; NCBI TaxID: NCBITaxon:5811;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-01 02:35:17	ID requested
⏵ 1	2024-10-31 10:20:34	announced

Dataset with its publication pending

submitter keyword: AP-MS, Guanylate binding proteins, immunity,mGBP2, vacuole-resident pathogens, Toxoplasma gondii

Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory Institute of Molecular Medicine I Heinrich Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027029
     1. Label: PRIDE project
     2. Name: mGBP2 interacting proteins during Toxoplasma gondii infection