<<< Full experiment listing

PXD026999

PXD026999 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleUltrasmall epiparasitic Saccharibacteria suppresses gingival inflammation and bone loss through host bacterial modulation
DescriptionSaccharibacteria (TM7) are obligate epibionts living on the surface of their host bacteria, and strongly correlated with dysbiotic microbiomes during periodontitis and other inflammatory diseases, suggesting they are putative pathogens. However, due to the recalcitrance of TM7 cultivation, no causal research has been conducted to investigate their role in inflammatory diseases. Here, we isolated multiple TM7 species on their host bacteria from periodontitis patients. These TM7 species reduced inflammation and consequential bone loss by modulating their host bacterial pathogenicity in mouse ligature-induced periodontitis model. Two host bacterial functions involved in collagen binding and utilization of eukaryotic sialic acid were identified as required for inducing bone loss and altered by TM7 association. This down-regulation of host bacterial pathogenicity by TM7 was shown for multiple TM7/host bacteria pairs, suggesting that, in contrast to their suspected pathogenic role, TM7 could protect mammalian hosts from inflammatory damage induced by their host bacteria.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:39:01.580.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD026999
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterFabian Schulte
SpeciesList scientific name: Schaalia odontolytica; NCBI TaxID: 1660;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-29 21:17:09ID requested
12023-03-11 00:07:07announced
22023-11-14 08:39:02announced2023-11-14: Updated project metadata.
Publication List
Chipashvili O, Utter DR, Bedree JK, Ma Y, Schulte F, Mascarin G, Alayyoubi Y, Chouhan D, Hardt M, Bidlack F, Hasturk H, He X, McLean JS, Bor B, Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation. Cell Host Microbe, 29(11):1649-1662.e7(2021) [pubmed]
10.6019/PXD026999;
Keyword List
submitter keyword: uncultivable, symbiosis, LC-MS,Proteome, oral microbiome
Contact List
Batileg Bor
contact affiliationAssistant Member of Staff, The Forsyth Institute
contact emailbbor@forsyth.org
lab head
Fabian Schulte
contact affiliationBrandeis University
contact emailfabianschulte@brandeis.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026999
PRIDE project URI
Repository Record List
[ + ]