PXD026999 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Ultrasmall epiparasitic Saccharibacteria suppresses gingival inflammation and bone loss through host bacterial modulation |
Description | Saccharibacteria (TM7) are obligate epibionts living on the surface of their host bacteria, and strongly correlated with dysbiotic microbiomes during periodontitis and other inflammatory diseases, suggesting they are putative pathogens. However, due to the recalcitrance of TM7 cultivation, no causal research has been conducted to investigate their role in inflammatory diseases. Here, we isolated multiple TM7 species on their host bacteria from periodontitis patients. These TM7 species reduced inflammation and consequential bone loss by modulating their host bacterial pathogenicity in mouse ligature-induced periodontitis model. Two host bacterial functions involved in collagen binding and utilization of eukaryotic sialic acid were identified as required for inducing bone loss and altered by TM7 association. This down-regulation of host bacterial pathogenicity by TM7 was shown for multiple TM7/host bacteria pairs, suggesting that, in contrast to their suspected pathogenic role, TM7 could protect mammalian hosts from inflammatory damage induced by their host bacteria. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:39:01.580.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD026999 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Fabian Schulte |
SpeciesList | scientific name: Schaalia odontolytica; NCBI TaxID: 1660; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-29 21:17:09 | ID requested | |
1 | 2023-03-11 00:07:07 | announced | |
⏵ 2 | 2023-11-14 08:39:02 | announced | 2023-11-14: Updated project metadata. |
Publication List
Chipashvili O, Utter DR, Bedree JK, Ma Y, Schulte F, Mascarin G, Alayyoubi Y, Chouhan D, Hardt M, Bidlack F, Hasturk H, He X, McLean JS, Bor B, Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation. Cell Host Microbe, 29(11):1649-1662.e7(2021) [pubmed] |
10.6019/PXD026999; |
Keyword List
submitter keyword: uncultivable, symbiosis, LC-MS,Proteome, oral microbiome |
Contact List
Batileg Bor |
contact affiliation | Assistant Member of Staff, The Forsyth Institute |
contact email | bbor@forsyth.org |
lab head | |
Fabian Schulte |
contact affiliation | Brandeis University |
contact email | fabianschulte@brandeis.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026999 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026999
- Label: PRIDE project
- Name: Ultrasmall epiparasitic Saccharibacteria suppresses gingival inflammation and bone loss through host bacterial modulation