PXD026962

PXD026962 is an original dataset announced via ProteomeXchange.

Title	Multi-omic Profiling of Plasma Identify Biomarkers and Pathogenesis of COVID-19 in Children
Description	Although people of all ages are susceptible to COVID-19, children usually develop less severe disease than adults. Little is known about the pathogenesis of COVID-19 in children. Herein, we conduct the plasma proteomic and metabolomic profiling of a cohort of COVID-19 children patients with mild symptoms, and uncovered that many proteins involved in immune response are significantly up-regulated in a stronger extent than in adults with COVID-19. Interestingly, more molecules involved in protective processes of reducing inflammation are also stimulated to antagonize the deleterious effect in both proteomic and metabolomic levels. By developing a machine learning-based pipeline, we prioritize two set of biomarker combinations, and identify 5 proteins and 5 metabolites as potentially children-specific biomarkers. Further experiments demonstrate these protective metabolites not only inhibit the expression of pro-inflammatory factors, but also suppress the viral replication. Taken together, our study not only discover the protective mechanisms in children with COVID-19, but also shed light on potential therapies targets for treating COVID-19.
HostingRepository	iProX
AnnounceDate	2021-06-28
AnnouncementXML	Submission_2023-02-20_22:59:57.062.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yang Qiu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	QTRAP 6500+

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-28 01:26:02	ID requested
1	2021-06-28 01:26:39	announced
⏵ 2	2023-02-20 22:59:58	announced	2023-02-21: Update information.

Wang C, Li X, Ning W, Gong S, Yang F, Fang C, Gong Y, Wu D, Huang M, Gou Y, Fu S, Ren Y, Yang R, Qiu Y, Xue Y, Xu Y, Zhou X, Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19. Theranostics, 11(16):8008-8026(2021) [pubmed]

submitter keyword: Multi-omic Profiling, COVID-19, Children

Xi Zhou
contact affiliation	Wuhan Institue of Virology, Chinese Academy of Sciences
contact email	zhouxi@wh.iov.cn
lab head
Yang Qiu
contact affiliation	Wuhan Institue of Virology, Chinese Academy of Sciences
contact email	yangqiu@wh.iov.cn
dataset submitter

iProX dataset URI