PXD026960

PXD026960 is an original dataset announced via ProteomeXchange.

Title	Identification of markers for migrasome detection
Description	The migrasome is a newly discovered cellular organelle in migrating cells, first described in 20151,2. Migrasomes have been proposed to mediate cell-cell communications and may exert physiological and pathological effects. In zebrafish embryos, generation of migrasomes has been observed during gastrulation, and migrasomes have been shown to be essential for organ morphogenesis during embryonic development (Personal communication). Although migrasome-like structures have been detected by transmission electron microscopy (TEM) in various organs including eye, lung and intestine, definitive evidence for the presence of migrasomes in vivo in mammals is still lacking. Exosomes are defined as 30–100 nm extracellular vesicles derived from the multivesicular body and are secreted by a variety of cell types. Exosomes have attracted great attention in clinical studies since they were detected in solid tissues, such as cartilage3, and in biological fluids, such as blood4. One of the most commonly used methods for detection of extracellular vesicles (EVs) is a biochemical approach using known marker proteins. This strategy allows researchers to identify EVs in complex biological samples such as body fluids and tissues, and thus provides great flexibility for detection of EVs in vivo. So far, there is no satisfactory marker for biochemical detection of migrasomes. TSPAN4 and integrin are known to be enriched on migrasomes1,5. However, both proteins are also present on exosomes6, making it difficult to distinguish the two structures biochemically based only on detection of these proteins. Imaging is the only approach for confirming the presence of migrasomes, but it is not compatible with most clinical samples. Thus, there is an urgent need to identify migrasome-specific markers.
HostingRepository	iProX
AnnounceDate	2021-06-28
AnnouncementXML	Submission_2023-02-02_19:04:27.518.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuaixin Gao
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-27 23:25:59	ID requested
1	2021-06-27 23:27:45	announced
⏵ 2	2023-02-02 19:04:28	announced	2023-02-03: Update publication information.

Zhao X, Lei Y, Zheng J, Peng J, Li Y, Yu L, Chen Y, Author Correction: Identification of markers for migrasome detection. Cell Discov, 8(1):32(2022) [pubmed]

submitter keyword: Identification , migrasome

Yang Chen
contact affiliation	Center for Precision Medicine Multi-Omics Research (CPMMR), Peking University Health Science Center
contact email	chenyang1816185048@bjmu.edu.cn
lab head
Shuaixin Gao
contact affiliation	Center for Precision Medicine Multi-Omics Research (CPMMR), Peking University Health Science Center
contact email	gaoshuaixin@126.com
dataset submitter

iProX dataset URI