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PXD026960

PXD026960 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of markers for migrasome detection
DescriptionThe migrasome is a newly discovered cellular organelle in migrating cells, first described in 20151,2. Migrasomes have been proposed to mediate cell-cell communications and may exert physiological and pathological effects. In zebrafish embryos, generation of migrasomes has been observed during gastrulation, and migrasomes have been shown to be essential for organ morphogenesis during embryonic development (Personal communication). Although migrasome-like structures have been detected by transmission electron microscopy (TEM) in various organs including eye, lung and intestine, definitive evidence for the presence of migrasomes in vivo in mammals is still lacking. Exosomes are defined as 30–100 nm extracellular vesicles derived from the multivesicular body and are secreted by a variety of cell types. Exosomes have attracted great attention in clinical studies since they were detected in solid tissues, such as cartilage3, and in biological fluids, such as blood4. One of the most commonly used methods for detection of extracellular vesicles (EVs) is a biochemical approach using known marker proteins. This strategy allows researchers to identify EVs in complex biological samples such as body fluids and tissues, and thus provides great flexibility for detection of EVs in vivo. So far, there is no satisfactory marker for biochemical detection of migrasomes. TSPAN4 and integrin are known to be enriched on migrasomes1,5. However, both proteins are also present on exosomes6, making it difficult to distinguish the two structures biochemically based only on detection of these proteins. Imaging is the only approach for confirming the presence of migrasomes, but it is not compatible with most clinical samples. Thus, there is an urgent need to identify migrasome-specific markers.
HostingRepositoryiProX
AnnounceDate2021-06-28
AnnouncementXMLSubmission_2023-02-02_19:04:27.518.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShuaixin Gao
SpeciesList scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-27 23:25:59ID requested
12021-06-27 23:27:45announced
22023-02-02 19:04:28announced2023-02-03: Update publication information.
Publication List
Zhao X, Lei Y, Zheng J, Peng J, Li Y, Yu L, Chen Y, Author Correction: Identification of markers for migrasome detection. Cell Discov, 8(1):32(2022) [pubmed]
Keyword List
submitter keyword: Identification , migrasome
Contact List
Yang Chen
contact affiliationCenter for Precision Medicine Multi-Omics Research (CPMMR), Peking University Health Science Center
contact emailchenyang1816185048@bjmu.edu.cn
lab head
Shuaixin Gao
contact affiliationCenter for Precision Medicine Multi-Omics Research (CPMMR), Peking University Health Science Center
contact emailgaoshuaixin@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI