PXD026929

PXD026929 is an original dataset announced via ProteomeXchange.

Title	miR141 Proteomic profile in Ovarian Cancer
Description	Over the last two decades, mounting evidence has demonstrated the aberrant expression of miRNAs in different human malignancies, including ovarian carcinomas. In this study, we found that miR-141 were secreted by ovarian cancer cells and transferred to the stromal cells by exosomal pathway. To clarify the mechanisms that miR-141 remodeling stromal fibroblast and reprogramming the relevant signals, miR-141 were overexpressed in WPMY-1 and their respective scrambled control were send for proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:38:20.351.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xueyu WANG
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-25 03:54:49	ID requested
1	2023-03-10 23:24:22	announced
⏵ 2	2023-11-14 08:38:22	announced	2023-11-14: Updated project metadata.

Mo Y, Leung LL, Mak CSL, Wang X, Chan WS, Hui LMN, Tang HWM, Siu MKY, Sharma R, Xu D, Tsui SKW, Ngan HYS, Yung MMH, Chan KKL, Chan DW, Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis. Mol Cancer, 22(1):4(2023) [pubmed]

submitter keyword: Exosome, LFQ, LC-MS/MS

Dr. David W. CHAN
contact affiliation	Assistant Professor DEPARTMENT OF OBSTETRICS & GYNAECOLOGY Faculty of Medicine The University of HOng Kong
contact email	dwchan@hku.hk
lab head
Xueyu WANG
contact affiliation	the University of Hong Kong
contact email	u3004659@connect.hku.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026929

PRIDE project URI

• PRIDE
  1. PXD026929
     1. Label: PRIDE project
     2. Name: miR141 Proteomic profile in Ovarian Cancer