PXD026892

PXD026892 is an original dataset announced via ProteomeXchange.

Title	A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
Description	KRAS mutant cancers, which feature the activation of multiple phosphorylation signaling pathways, remain a major challenge for cancer therapy. This study provides a landscape of the proteomics and phosphoproteomics of KRAS mutant cancers by analyzing different KRAS mutant human cancer cell lines across different tissues types. By integrating multi-omics analysis, we identify different robust subsets, which recapitulate the histological, pathological and prognostic features of human cancers.
HostingRepository	iProX
AnnounceDate	2021-06-23
AnnouncementXML	Submission_2023-08-27_21:05:41.452.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linhui Zhai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-23 19:52:17	ID requested
1	2021-07-29 00:34:32	announced
⏵ 2	2023-08-27 21:05:42	announced	2023-08-28: Update publication information.

Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M, Tan M, A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 81(19):4076-4090.e8(2021) [pubmed]

submitter keyword: KRAS, proteomics, phosphoproteomics

Minjia Tan
contact affiliation	Shanghai Institute of Materia Medica
contact email	mjtan@simm.ac.cn
lab head
Linhui Zhai
contact affiliation	Shanghai Institute of Materia Medica
contact email	zhailinhui@163.com
dataset submitter

iProX dataset URI