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PXD026892

PXD026892 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
DescriptionKRAS mutant cancers, which feature the activation of multiple phosphorylation signaling pathways, remain a major challenge for cancer therapy. This study provides a landscape of the proteomics and phosphoproteomics of KRAS mutant cancers by analyzing different KRAS mutant human cancer cell lines across different tissues types. By integrating multi-omics analysis, we identify different robust subsets, which recapitulate the histological, pathological and prognostic features of human cancers.
HostingRepositoryiProX
AnnounceDate2021-06-23
AnnouncementXMLSubmission_2023-08-27_21:05:41.452.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLinhui Zhai
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-23 19:52:17ID requested
12021-07-29 00:34:32announced
22023-08-27 21:05:42announced2023-08-28: Update publication information.
Publication List
Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M, Tan M, A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 81(19):4076-4090.e8(2021) [pubmed]
Keyword List
submitter keyword: KRAS, proteomics, phosphoproteomics
Contact List
Minjia Tan
contact affiliationShanghai Institute of Materia Medica
contact emailmjtan@simm.ac.cn
lab head
Linhui Zhai
contact affiliationShanghai Institute of Materia Medica
contact emailzhailinhui@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI