PXD026892
PXD026892 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies |
Description | KRAS mutant cancers, which feature the activation of multiple phosphorylation signaling pathways, remain a major challenge for cancer therapy. This study provides a landscape of the proteomics and phosphoproteomics of KRAS mutant cancers by analyzing different KRAS mutant human cancer cell lines across different tissues types. By integrating multi-omics analysis, we identify different robust subsets, which recapitulate the histological, pathological and prognostic features of human cancers. |
HostingRepository | iProX |
AnnounceDate | 2021-06-23 |
AnnouncementXML | Submission_2023-08-27_21:05:41.452.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Linhui Zhai |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-06-23 19:52:17 | ID requested | |
1 | 2021-07-29 00:34:32 | announced | |
⏵ 2 | 2023-08-27 21:05:42 | announced | 2023-08-28: Update publication information. |
Publication List
Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M, Tan M, A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 81(19):4076-4090.e8(2021) [pubmed] |
Keyword List
submitter keyword: KRAS, proteomics, phosphoproteomics |
Contact List
Minjia Tan | |
---|---|
contact affiliation | Shanghai Institute of Materia Medica |
contact email | mjtan@simm.ac.cn |
lab head | |
Linhui Zhai | |
contact affiliation | Shanghai Institute of Materia Medica |
contact email | zhailinhui@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |