PXD026867

PXD026867 is an original dataset announced via ProteomeXchange.

Title	Overexpression of Ndr2 disturbs hippocampal circuitry and function
Description	The Ndr (nuclear Dbf2-related) family members are highly conserved serine/threonine protein kinases, which function in many cellular processes extending from cytokinesis to neurite outgrowth. In humans, the NDR2 gene is located in a microduplication hotspot on chromosome 12p that is associated with intellectual disabilities in several individuals. To address a putative contribution of Ndr2 overexpression to such cognitive dysfunctions we generated conditional transgenic mice overexpressing Ndr2 in postmigratory forebrain neurons. Proteomic analysis identifies several interaction partners of transgenic Ndr2 relevant to MF maturation. including the leucin-rich repeat kinase 2 (Lrrk2).
HostingRepository	PRIDE
AnnounceDate	2021-07-16
AnnouncementXML	Submission_2021-07-15_22:33:40.216.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thilo Kaehne
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-22 08:22:37	ID requested
⏵ 1	2021-07-15 22:33:40	announced

Dataset with its publication pending

submitter keyword: transgene NDR2 mouse, LC-MS/MS, interactomics

Prof. Dr. Thilo Kaehne
contact affiliation	University Magdeburg, Medical School, Institute of Exptl. Internal Medicine, Leipzigerstr. 44, 39120 Magdeburg, Germany
contact email	kaehne@med.ovgu.de
lab head
Thilo Kaehne
contact affiliation	University Magdeburg
contact email	kaehne@med.ovgu.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026867
     1. Label: PRIDE project
     2. Name: Overexpression of Ndr2 disturbs hippocampal circuitry and function