PXD026858

PXD026858 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of the murine primary placenta
Description	The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid (FA) carriers in specific placental compartments were upregulated according to gestational age, and metabolomic analysis also showed that the placental transport of FAs increased in a time-dependent manner. Further analysis of two mutant mice models with embryonic lethality revealed that lipid-related signatures could reflect the functional state of the placenta. Our findings highlight the importance of the nutrient transport function of the primary placenta in the early gestational period and the role of lipids in embryonic development.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:02:38.926.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jeonghun Yeom
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-22 02:53:25	ID requested
1	2023-09-05 19:40:36	announced
2	2023-11-14 09:05:03	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:02:39	announced	2024-10-22: Updated project metadata.

10.1093/biolre/ioab219;

Lee JG, Kim G, Park SG, Yon JM, Yeom J, Song HE, Cheong SA, Lim JS, Sung YH, Kim K, Yoo HJ, Hong EJ, Nam KH, Seong JK, Kim CJ, Nam SY, Baek IJ, . Biol Reprod, 106(3):583-596(2022) [pubmed]

submitter keyword: Murine, placenta

Kyunggon Kim
contact affiliation	1 Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea 2 Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea 3 Clinical Proteomics Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Seoul 05505, Republic of Korea 4 Bio-Medical Institute of Technology, Asan Medical Center, Seoul 05505, Republic of Korea
contact email	kkkon1@amc.seoul.kr
lab head
Jeonghun Yeom
contact affiliation	prometabio co., ltd.
contact email	nature8309@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD026858

PRIDE project URI

• PRIDE
  1. PXD026858
     1. Label: PRIDE project
     2. Name: Proteome analysis of the murine primary placenta