PXD026854
PXD026854 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | SARS-CoV-2 infection causes transient olfactory dysfunction in mice |
Description | SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in human, and olfactory dysfunction represents as one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mechanism how SARS-CoV-2 infection leads to olfactory disorders remains elusive. Herein we demonstrate intranasal inoculation of SARS-CoV-2 induces robust viral replication in the olfactory epithelium (OE), not olfactory bulb (OB), resulting in transient olfactory dysfunction in humanized ACE2 mice. The sustentacular cells and Bowman's gland cells in the OE were identified as the major target cells of SARS-CoV-2 before the invasion into olfactory sensory neurons. Remarkably, SARS-CoV-2 infection triggers massive cell death and immune cell infiltration, and directly impairs the uniformity of OE structure. Combined transcriptomic and quantitative proteomic analyses reveal the induction of antiviral and inflammatory responses, as well as the downregulation of olfactory receptor (OR) genes in the OE from the infected animals. Overall, our mouse model recapitulates the olfactory dysfunction in COVID-19 patients, and provides critical clues to understand the physiological basis for extrapulmonary manifestations of COVID-19. |
HostingRepository | iProX |
AnnounceDate | 2021-06-22 |
AnnouncementXML | Submission_2023-02-09_20:04:10.912.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yao Zhang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-06-21 23:03:08 | ID requested | |
1 | 2021-06-21 23:03:40 | announced | |
⏵ 2 | 2023-02-09 20:04:12 | announced | 2023-02-10: Update publication information. |
Publication List
Ye Q, Zhou J, He Q, Li RT, Yang G, Zhang Y, Wu SJ, Chen Q, Shi JH, Zhang RR, Zhu HM, Qiu HY, Zhang T, Deng YQ, Li XF, Liu JF, Xu P, Yang X, Qin CF, SARS-CoV-2 infection in the mouse olfactory system. Cell Discov, 7(1):49(2021) [pubmed] |
Keyword List
submitter keyword: SARS-CoV-2, Anosmia, Olfactory dysfunction, Olfactory receptor, Regeneration, Immune response |
Contact List
Ping Xu | |
---|---|
contact affiliation | Beijing Proteome Research Center |
contact email | xuping_bprc@126.com |
lab head | |
Yao Zhang | |
contact affiliation | Beijing Proteome Research Center |
contact email | zhangyaowsw@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |