PXD026835

PXD026835 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A quantitative proteomics study for assessing rodent thyroid toxicity
Description	Here, we aimed to use TMT based quantitative proteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (high, low) and three treatment time points (short, long, and long+recovery) were investigated, allowing insights into the mode of actions during thyroid toxicity. Proteomics were applied to liver and thyroid tissues.
HostingRepository	PRIDE
AnnounceDate	2024-10-25
AnnouncementXML	Submission_2024-10-25_06:19:29.696.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026835
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Zhipeng Wang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-21 03:04:22	ID requested
⏵ 1	2024-10-25 06:19:30	announced

Publication List

10.1007/S00204-024-03876-2;
10.6019/PXD026835;

10.1007/S00204-024-03876-2;

10.6019/PXD026835;

Keyword List

submitter keyword: TMT, Toxicity, Phenytoin, PTU,Thyroid

submitter keyword: TMT, Toxicity, Phenytoin, PTU,Thyroid

Contact List

Kristin Schubert
contact affiliation	Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH – UFZ, 04318 Leipzig, Germany
contact email	kristin.schubert@ufz.de
lab head
Zhipeng Wang
contact affiliation	Helmholtz Centre for Environmental Research
contact email	zhipeng.wang@ufz.de
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD026835
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD026835

PRIDE project URI

Repository Record List

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