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PXD026835

PXD026835 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA quantitative proteomics study for assessing rodent thyroid toxicity
DescriptionHere, we aimed to use TMT based quantitative proteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (high, low) and three treatment time points (short, long, and long+recovery) were investigated, allowing insights into the mode of actions during thyroid toxicity. Proteomics were applied to liver and thyroid tissues.
HostingRepositoryPRIDE
AnnounceDate2024-10-25
AnnouncementXMLSubmission_2024-10-25_06:19:29.696.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD026835
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterZhipeng Wang
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-21 03:04:22ID requested
12024-10-25 06:19:30announced
Publication List
10.1007/S00204-024-03876-2;
10.6019/PXD026835;
Keyword List
submitter keyword: TMT, Toxicity, Phenytoin, PTU,Thyroid
Contact List
Kristin Schubert
contact affiliationDepartment of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH – UFZ, 04318 Leipzig, Germany
contact emailkristin.schubert@ufz.de
lab head
Zhipeng Wang
contact affiliationHelmholtz Centre for Environmental Research
contact emailzhipeng.wang@ufz.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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