PXD026784

PXD026784 is an original dataset announced via ProteomeXchange.

Title	Biochemical network analysis of protein-protein interactions to monitor the course of T1 bladder cancer patients
Description	Mass spectrometry-based personalized medicine was used to uncover key information in T1-stage bladder cancer (BC) patients and used as a tool to aid clinical decision making. The urinary proteome of patients with recurring versus non-recurring T1-stage BC were compared to uncover information for clinical decision making. Our results suggest the urinary myeloperoxidase to cubilin ratio as a new tool to address recurrence as well as dysregulation of the inflammatory and immune systems as drivers of a worsening disease course. Furthermore, dysregulation of neutrophil extracellular traps (NETs) is pinpointed as the leading way by which malignancy progress in BC showing the formation of an inflammatory microenvironment that facilitates immune cell-matrix cross-talk and promotes a state of chronic inflammation. We conclude that inflammation dysregulation is an important driver of BC recurrence and progression, and that anti-inflammatory or immune checkpoint therapies should be further explored in the treatment of patients with BC.
HostingRepository	PRIDE
AnnounceDate	2025-11-11
AnnouncementXML	Submission_2025-11-11_01:29:38.322.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hugo M. Santos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-18 03:50:29	ID requested
⏵ 1	2025-11-11 01:29:38	announced

10.1016/J.JPROT.2023.104865;

submitter keyword: myeloperoxidase (MPO)

cubilin (CUBN).,Bladder cancer

urine

proteomics

label-free quantification

mass spectrometry

tumor associated neutrophile, neutrophil extracellular traps

Hugo M. Santos
contact affiliation	NOVA School of Science and Technology, NOVA University of Lisbon (lab head)
contact email	hmsantos@fct.unl.pt
lab head
Hugo M. Santos
contact affiliation	LAQV-REQUIMTE, Department of Chemistry, School of Science and Technology, NOVA University of Lisbon
contact email	hmsantos@fct.unl.pt
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD026784

PRIDE project URI

• PRIDE
  1. PXD026784
     1. Label: PRIDE project
     2. Name: Biochemical network analysis of protein-protein interactions to monitor the course of T1 bladder cancer patients