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PXD026732

PXD026732 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffects of dietary protein from different sources on biotransformation, antioxidation, inflammation and exerted a great impact on lipid metabolism and mitochondrial oxidative phosphorylation in the rat liver
DescriptionIn this work, the effects of different sources of meat protein on liver metabolic enzymes were investigated. Rats were fed for 90 days with semisynthetic diets in which casein was fully replaced by isolated soybean, fish, chicken, pork, or beef proteins. Then, liver proteomics was performed using iTRAQ and LC−ESI−MS/MS. The results indicated that intake of meat protein diets significantly reduced the protein levels of CYP450s, GSTs, UGTs, and SULTs compared to those of the casein and soybean protein diet groups. The total antioxidant capacity and lipid peroxidation values did not differ between four meat protein diet groups and the casein diet group. However, GSH activity in the fish, chicken, and beef protein groups was significantly higher than those of the casein and soybean protein groups. The beef protein diet significantly upregulated the expression of immune-related proteins. The Keap1-Nrf2-ARE signaling pathway was suggested to involve the diet-mediated regulation of biotransformation, inflammation, and redox status.
HostingRepositoryPRIDE
AnnounceDate2024-02-12
AnnouncementXMLSubmission_2024-02-12_09:03:45.401.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZixin Huang
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListiTRAQ8plex-116 reporter+balance reagent acylated residue
InstrumentThermo Fisher Scientific instrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-15 15:44:11ID requested
12022-02-17 04:38:17announced
22024-02-12 09:03:47announced2024-02-12: Updated project metadata.
Publication List
10.3389/fnut.2021.719144;
Shi X, Huang Z, Zhou G, Li C, Dietary Protein From Different Sources Exerted a Great Impact on Lipid Metabolism and Mitochondrial Oxidative Phosphorylation in Rat Liver. Front Nutr, 8():719144(2021) [pubmed]
Keyword List
submitter keyword: rat liver, proteomics,biotransformation, inflammation,dietary protein
Contact List
Chunbao Li
contact affiliationCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing, China
contact emailchunbao.li@njau.edu.cn
lab head
Zixin Huang
contact affiliation570141984@qq.com
contact email2020208013@stu.njau.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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