PXD026695

PXD026695 is an original dataset announced via ProteomeXchange.

Title	Inhibition of the mitochondrial disulfide relay system impairs liver cancer cell proliferation
Description	Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into the ALR role in the DRS in HCC, we thus pharmacologically inhibited ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. These effects were mostly reversed by supplementation with bioavailable hemin b, linking the DRS, and specifically ALR function, to mitochondrial iron homeostasis. Since tumor cells are known for their increased iron demand and since increased iron levels in cancer are associated with poor clinical outcome, these results help to further advance the intricate relation between iron and mitochondria in liver cancer.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:30:25.212.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ann-Christine König
SpeciesList	scientific name: Rattus rattus (Black rat); NCBI TaxID: 10117;
ModificationList	carbamoylated residue; deaminated residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-14 07:56:06	ID requested
⏵ 1	2022-02-17 04:30:26	announced

Kabiri Y, Fuhrmann A, Becker A, Jedermann L, Eberhagen C, K, ö, nig AC, Silva TB, Borges F, Hauck SM, Michalke B, Knolle P, Zischka H, Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation. Front Cell Dev Biol, 9():725474(2021) [pubmed]

submitter keyword: mitochondria, HCC, disulfide relay, iron, heme

Hans Zischka
contact affiliation	Institute of Toxicology and Environmental Hygiene, Technical University of Munich, School of Medicine, Munich, Germany Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
contact email	zischka@helmholtz-muenchen.de
lab head
Ann-Christine König
contact affiliation	HMGU Core Facility Proteomics
contact email	ann-christine.koenig@helmholtz-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026695

PRIDE project URI

• PRIDE
  1. PXD026695
     1. Label: PRIDE project
     2. Name: Inhibition of the mitochondrial disulfide relay system impairs liver cancer cell proliferation