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PXD026694

PXD026694 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSerum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia (BILE)
DescriptionPrimary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well as from PSC patients divided into groups according to endoscopic retrograde cholangiography score (with a score of >4 indicating advanced disease) and presence or absence of biliary dysplasia/CCA. Further analyses subsequently identified multiple candidates of new noninvasive serum markers for the diagnosis of PSC, as well as new markers for the prediction of the risk of disease progression and biliary neoplasia for patients already diagnosed with PSC.
HostingRepositoryPRIDE
AnnounceDate2022-08-03
AnnouncementXMLSubmission_2022-08-03_15:51:24.006.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSakari Joenväärä
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-14 07:32:37ID requested
12022-08-03 15:51:24announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, Bile. PSC. Mass spectrometry
Contact List
Risto Renkonen
contact affiliationFaculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
contact emailristo.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliationHelsinki University
contact emailsakari.joenvaara@helsinki.fi
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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