PXD026694

PXD026694 is an original dataset announced via ProteomeXchange.

Title	Serum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia (BILE)
Description	Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by biliary strictures, cholestasis, and an increased risk of cholangiocarcinoma (CCA). Here, we have used label-free quantitative proteomics to analyze serum and bile samples from non-PSC controls and PSC patients, as well as from PSC patients divided into groups according to endoscopic retrograde cholangiography score (with a score of >4 indicating advanced disease) and presence or absence of biliary dysplasia/CCA. Further analyses subsequently identified multiple candidates of new noninvasive serum markers for the diagnosis of PSC, as well as new markers for the prediction of the risk of disease progression and biliary neoplasia for patients already diagnosed with PSC.
HostingRepository	PRIDE
AnnounceDate	2022-08-03
AnnouncementXML	Submission_2022-08-03_15:51:24.006.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-14 07:32:37	ID requested
⏵ 1	2022-08-03 15:51:24	announced

Dataset with its publication pending

submitter keyword: Human, Bile. PSC. Mass spectrometry

Risto Renkonen
contact affiliation	Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD026694

PRIDE project URI

• PRIDE
  1. PXD026694
     1. Label: PRIDE project
     2. Name: Serum and bile proteomics reveal candidates for new noninvasive serum markers of primary sclerosing cholangitis and of risk of disease progression and biliary neoplasia (BILE)