PXD026677

PXD026677 is an original dataset announced via ProteomeXchange.

Title	The attenuating effect of low-intensity pulsed ultrasound on hypoxia-induced chondrocyte damage in TMJ osteoarthritis based on TMT labeling quantitative proteomic analysis
Description	Temporomandibular joint osteoarthritis (TMJOA) is a common group of clinical diseases and is an important subtype of temporomandibular joint disorder (TMD). Increased intrajoint pressure or weakened penetration can exacerbate the hypoxic state of the condylar cartilage microenvironment. In this study, TMT labeling quantitative proteomic technology was used to comprehensively explore the impacts of and pathways affected by LIPUS on the biological functions of chondrocytes under hypoxic conditions. Bioinformatic analysis revealed differentially expressed proteins (DEPs) in the N group versus the L group and the L group versus the LP group. Considering the results of gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interaction (PPI) network analyses, we hypothesized that LIPUS can activate the FAK signaling pathway. This study identified a new molecular marker to determine the efficacy of LIPUS in TMJOA, providing a theoretical basis for the clinical application of LIPUS in the treatment of TMJOA.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:27:51.015.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Geng
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-14 05:34:37	ID requested
⏵ 1	2022-02-17 04:27:51	announced

Du S, Liang C, Sun Y, Ma B, Gao W, Geng W, The Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis. Front Pharmacol, 12():752734(2021) [pubmed]

submitter keyword: low-intensity pulsed ultrasound (LIPUS), hypoxia, chondrocyte, TMJOA, TMT labeling proteomics

Wei Geng
contact affiliation	Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China
contact email	gengwei717@163.com
lab head
Wei Geng
contact affiliation	Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University
contact email	gengwei717@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026677

PRIDE project URI

• PRIDE
  1. PXD026677
     1. Label: PRIDE project
     2. Name: The attenuating effect of low-intensity pulsed ultrasound on hypoxia-induced chondrocyte damage in TMJ osteoarthritis based on TMT labeling quantitative proteomic analysis