PXD026645

PXD026645 is an original dataset announced via ProteomeXchange.

Title	Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy
Description	To investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices from human dermal fibroblasts (HDF), skin melanoma associated fibroblasts (MAF) and two different lymph node fibroblast reticular cells (FRC) were denuded of cells and their composition was analyzed by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2021-11-12
AnnouncementXML	Submission_2021-11-11_23:50:04.832.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AUDEBERT Stephane
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-11 06:23:41	ID requested
⏵ 1	2021-11-11 23:50:05	announced

Dataset with its publication pending

submitter keyword: melanoma, extracellular matrix, DDR, targeted therapies, resistance, LC-MSMS

Deckert Marcel
contact affiliation	C3M – Inserm U1065 Centre Méditerranéen de Médecine Moléculaire Team: Microenvironment, signaling and cancer Bâtiment Universitaire ARCHIMED 151 route Saint Antoine de Ginestière BP 2 3194 06204 NICE CEDEX 3
contact email	Marcel.DECKERT@unice.fr
lab head
AUDEBERT Stephane
contact affiliation	Pharmacology department
contact email	stephane.audebert@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD026645

PRIDE project URI

• PRIDE
  1. PXD026645
     1. Label: PRIDE project
     2. Name: Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy