PXD026644

PXD026644 is an original dataset announced via ProteomeXchange.

Title	Quantitative glycoproteomics of human milk and their association with atopic disease
Description	Children who grow up on farms have a lower risk of developing childhood atopic disease. Although human milk proteins are heavily glycosylated, there is a lack of studies investigating the milk glycoproteome. In this study, we have used label-free quantitative proteomics to analyze milk samples from Rochester and Older Order Mennonite mothers, two populations with different lifestyles, exposures, and risk of allergic disease. We identified multiple N-glycopeptides with significantly different abundances between the two communities and four N-glycopeptides that may have a protective effect against the development of atopic disease. The findings of this study indicate that the differential glycosylation of milk proteins may affect the development of atopic disease, something previously uninvestigated.
HostingRepository	PRIDE
AnnounceDate	2022-06-09
AnnouncementXML	Submission_2022-06-09_07:37:10.011.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-11 06:23:03	ID requested
⏵ 1	2022-06-09 07:37:10	announced

Holm M, Saraswat M, Joenv, ä, ä, r, ä S, Seppo A, Looney RJ, Tohmola T, Renkonen J, Renkonen R, J, ä, rvinen KM, Quantitative glycoproteomics of human milk and association with atopic disease. PLoS One, 17(5):e0267967(2022) [pubmed]

submitter keyword: Human, Milk, N-glycoproteins, Mass spectrometry

Risto Renkonen
contact affiliation	Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, Helsinki, Finlan
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD026644

PRIDE project URI

• PRIDE
  1. PXD026644
     1. Label: PRIDE project
     2. Name: Quantitative glycoproteomics of human milk and their association with atopic disease