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PXD026643

PXD026643 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSalt-inhibited protein 2-hydroxyisobutyrylation affects silique development of Arabidopsis thaliana
DescriptionLysine 2-hydroxyisobutyrylation (Khib) is one of the newly discovered post-translational modifications (PTMs) through protein acylation. It has been reported to be widely distribute in both eukaryotes and prokaryotes, and plays an important role in chromatin conformation change, gene transcription, subcellular localization, protein-protein interaction, signal transduction, and cellular proliferation. In this study, we compared the siliques from Arabidopsis thaliana under salt stress (Ss) with those in the control (Cs). The results showed that this highly conserved modification was abundant in siliques. However, there were certain significant differences between the Ss and the Cs: 3810 normalized 2-hydroxyisobutyrylation sites on 1254 proteins were identified in siliques under salt stress, and lysine 2-hydroxyisobutyrylation was up-regulated at 96 sites on 78 proteins while down-regulated at 282 sites on 205 proteins in Ss. In the KEGG pathway enrichment analysis, Khib-modified proteins were enriched in several pathways related to energy metabolism, including gluconeogenesis pathway, pentose phosphate pathway, and pyruvate metabolism. Overall, our work reveals the first systematic analysis of Khib proteome in Arabidopsis siliques under salt stress, and sheds a light on the future studies on the regulatory mechanisms of Khib during the salt stress response of plants.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-17_04:24:53.821.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGeriqiqige Hong
SpeciesList scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentTMT quantitation analysis
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-11 03:55:17ID requested
12022-02-17 04:24:54announced
Publication List
Hong G, Su X, Xu K, Liu B, Wang G, Li J, Wang R, Zhu M, Li G, Salt stress downregulates 2-hydroxybutyrylation in Arabidopsis siliques. J Proteomics, 250():104383(2022) [pubmed]
Keyword List
submitter keyword: Arabidopsis thaliana. Silique. Lysine 2-hydroxyisobutyrylation. Salt stress
Contact List
Guojing Li
contact affiliationInner Mongolia Key Laboratory of Plant Stress Physiology and Molecular Biology, Inner Mongolia Agricultural University
contact emailliguojing@imau.edu.cn
lab head
Geriqiqige Hong
contact affiliationInner Mongolia Key Laboratory of Plant Stress Physiology and Molecular Biology, Inner Mongolia Agricultural University
contact emailhonggeriqiqige@126.com
dataset submitter
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Dataset FTP location
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