PXD026615
PXD026615 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comprehensive and systematic characterization of novel nanodrug conjugate based on multi-functionalized magnetic iron-nanoparticles conjugated with cisplatin derivative: From the chemistry to the animal model |
Description | Nanodrugs need a completely characterization by both chemically and biological point of view. As nanoparticles have evolved as multi-functional systems combining different custom anchorages, their pharmacological involvements require more comprehensive analysis. In this work, we present the design and synthesis of novel iron-NPs conjugated with a cisplatin derivate and their biological evaluation by quantitative proteomics approches. To decipher detailed insights related to the NP interactions with environment (as protein corona) and pharmacodynamics functionalities of the nanodrugs conjugates, LC-MS/MS analysis was perform to stablish protein profile. Biocompatibility and animal model provided complete insights of the potential of multifunctional iron NPs. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-12 |
AnnouncementXML | Submission_2022-08-12_03:27:33.791.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD026615 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Ángela-Patricia Hernández |
SpeciesList | scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-06-10 06:01:33 | ID requested | |
⏵ 1 | 2022-08-12 03:27:34 | announced |
Publication List
Hern, á, ndez Á P, Micaelo A, Pi, ñ, ol R, Garc, í, a-Vaquero ML, Aramayona JJ, Criado JJ, Rodriguez E, S, á, nchez-Gallego JI, Landeira-Vi, ñ, uela A, Juanes-Velasco P, D, í, ez P, G, ó, ngora R, Jara-Acevedo R, Orfao A, Miana-Mena J, Mu, ñ, oz MJ, Villanueva S, Mill, á, n Á, Fuentes M, Comprehensive and systematic characterization of multi-functionalized cisplatin nano-conjugate: from the chemistry and proteomic biocompatibility to the animal model. J Nanobiotechnology, 20(1):341(2022) [pubmed] |
Keyword List
submitter keyword: Nanoparticles (NPs), Cisplatin, LC-MS/MS, protein corona, protein labeling, intracellular pathways |
Contact List
Manuel Fuentes García | |
---|---|
contact affiliation | Department of Medicine and General Service of Cytometry, Cancer Research Centre-IBMCC, IBSAL. University of Salamanca-CSIC, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain |
contact email | mfuentes@usal.es |
lab head | |
Ángela-Patricia Hernández | |
contact affiliation | Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16/12/00400, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Spain |
contact email | angytahg@usal.es |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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