PXD026615

PXD026615 is an original dataset announced via ProteomeXchange.

Title	Comprehensive and systematic characterization of novel nanodrug conjugate based on multi-functionalized magnetic iron-nanoparticles conjugated with cisplatin derivative: From the chemistry to the animal model
Description	Nanodrugs need a completely characterization by both chemically and biological point of view. As nanoparticles have evolved as multi-functional systems combining different custom anchorages, their pharmacological involvements require more comprehensive analysis. In this work, we present the design and synthesis of novel iron-NPs conjugated with a cisplatin derivate and their biological evaluation by quantitative proteomics approches. To decipher detailed insights related to the NP interactions with environment (as protein corona) and pharmacodynamics functionalities of the nanodrugs conjugates, LC-MS/MS analysis was perform to stablish protein profile. Biocompatibility and animal model provided complete insights of the potential of multifunctional iron NPs.
HostingRepository	PRIDE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_03:27:33.791.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026615
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ángela-Patricia Hernández
SpeciesList	scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-10 06:01:33	ID requested
⏵ 1	2022-08-12 03:27:34	announced

Hern, á, ndez Á P, Micaelo A, Pi, ñ, ol R, Garc, í, a-Vaquero ML, Aramayona JJ, Criado JJ, Rodriguez E, S, á, nchez-Gallego JI, Landeira-Vi, ñ, uela A, Juanes-Velasco P, D, í, ez P, G, ó, ngora R, Jara-Acevedo R, Orfao A, Miana-Mena J, Mu, ñ, oz MJ, Villanueva S, Mill, á, n Á, Fuentes M, Comprehensive and systematic characterization of multi-functionalized cisplatin nano-conjugate: from the chemistry and proteomic biocompatibility to the animal model. J Nanobiotechnology, 20(1):341(2022) [pubmed]

submitter keyword: Nanoparticles (NPs), Cisplatin, LC-MS/MS, protein corona, protein labeling, intracellular pathways

Manuel Fuentes García
contact affiliation	Department of Medicine and General Service of Cytometry, Cancer Research Centre-IBMCC, IBSAL. University of Salamanca-CSIC, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain
contact email	mfuentes@usal.es
lab head
Ángela-Patricia Hernández
contact affiliation	Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16/12/00400, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Spain
contact email	angytahg@usal.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026615
     1. Label: PRIDE project
     2. Name: Comprehensive and systematic characterization of novel nanodrug conjugate based on multi-functionalized magnetic iron-nanoparticles conjugated with cisplatin derivative: From the chemistry to the animal model