PXD026609

PXD026609 is an original dataset announced via ProteomeXchange.

Title	Leucyl-tRNA synthetase is a tumor suppressor in breast cancer and enables tumor suppressive translation
Description	In this study, we identify leucyl-tRNA synthetase (LARS) as a breast tumor suppressor. To identify the mechanism underlying LARS-mediated breast tumor suppression, we conducted TMT-proteomics in PyMT mouse tumors with monoallelic genetic deletion of LARS in the mammary tumor compartment. The analyses implicate LARS as a regulator of leucine-rich protein translation resulting in downregulation of candidate leucine-rich tumor suppressor genes.
HostingRepository	PRIDE
AnnounceDate	2022-01-10
AnnouncementXML	Submission_2022-01-10_13:48:55.712.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Soren Heissel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-10 03:01:38	ID requested
⏵ 1	2022-01-10 13:48:56	announced

Dataset with its publication pending

submitter keyword: LARS, TMT, LC-MS, breast cancer

Sohail Tavazoie
contact affiliation	Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
contact email	stavazoie@rockefeller.edu
lab head
Soren Heissel
contact affiliation	Research Support Specialist
contact email	sheissel@rockefeller.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/01/PXD026609

PRIDE project URI

• PRIDE
  1. PXD026609
     1. Label: PRIDE project
     2. Name: Leucyl-tRNA synthetase is a tumor suppressor in breast cancer and enables tumor suppressive translation