PXD026587

PXD026587 is an original dataset announced via ProteomeXchange.

Title	Shotgun proteomic elucidation of Synergistic mechanisms of Cannabidiol and SN-38 in the MCF7 cells
Description	We evaluted the synergyistic interactions of cannabidiol (CBD) with standard chemotherapeutic agents such as Docetaxel (DOC), doxorubicin (DOX), paclitaxel (PTX), vinorelbine (VIN), and 7-Ethyl-10-hydroxycamptothecin (SN38) in MCf7 cells ultising different synergy metrics. Then we explored the synergistic mechanisms on the proteome level of the most synergistic combination (CBD and SN38 in a molar ratio of 371:1, respectively)
HostingRepository	PRIDE
AnnounceDate	2021-11-03
AnnouncementXML	Submission_2021-11-03_05:45:29.467.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026587
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Muhammad Ali
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-09 01:26:50	ID requested
⏵ 1	2021-11-03 05:45:30	announced

Alsherbiny MA, Bhuyan DJ, Low MN, Chang D, Li CG, Synergistic Interactions of Cannabidiol with Chemotherapeutic Drugs in MCF7 Cells: Mode of Interaction and Proteomics Analysis of Mechanisms. Int J Mol Sci, 22(18):(2021) [pubmed]

submitter keyword: MCF7, Synergy, SN-38, 7-Ethyl-10-hydroxycamptothecin, CBD, Cannabidiol, proteomics, Breast cancer

Chun Guang Li
contact affiliation	NICM Heatlth research institute, Western Sydney University, NSW, Australia.
contact email	c.li@westernsydney.edu.au
lab head
Muhammad Ali
contact affiliation	Western Sydney University Cairo University
contact email	muhammad.alsherbiny@pharma.cu.edu.eg
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026587
     1. Label: PRIDE project
     2. Name: Shotgun proteomic elucidation of Synergistic mechanisms of Cannabidiol and SN-38 in the MCF7 cells