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PXD026581

PXD026581 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleData Descriptor: Proteomic profiling across breast cancer cell lines and models
DescriptionWe performed quantitative proteomics of 60 human-derived breast cancer cell lines to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to identify and characterize the subtypes of breast cancer and showed that they conform with known transcriptional subtypes, revealing that molecular subtypes are preserved even in under-sampled molecular feature datasets. The datasets are made freely available as a public resource on the LINCS portal. We anticipate that these datasets, either in isolation or combination with measurements of complementary molecular features, can be mined for the purpose of predicting drug response, informing context in mathematical models of signaling pathways, inferring cell-type or subtype specific pathways activities of unperturbed cellular states, and identifying markers of sensitivity or resistance to therapeutics.
HostingRepositoryPRIDE
AnnounceDate2023-03-15
AnnouncementXMLSubmission_2023-03-15_15:01:47.691.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGaryBradshaw
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-08 23:14:36ID requested
12023-03-15 15:01:48announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: protein expression, TMT, proteomic profiling, quantitative proteomics,Breast cancer cell lines
Contact List
Peter K. Sorger,PhD
contact affiliationOtto Krayer Professor Department of Systems Biology Head of the Harvard Program in Therapeutic Sciences - HiTS Harvard Medical School
contact emailpeter_sorger@hms.harvard.edu
lab head
GaryBradshaw
contact affiliationHarvard Medical School
contact emailGary_bradshaw@hms.harvard.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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