PXD026529

PXD026529 is an original dataset announced via ProteomeXchange.

Title	Spatial multiomics identifies CNS drug targets for progressive multiple sclerosis
Description	Progressive multiple sclerosis (MS) is driven by persistent neuronal injury, causes cumulative disability and is refractory to current treatments. Drug development to prevent disease progression is an urgent and unmet clinical need, yet is constrained by an incomplete understanding of its complex pathogenesis. Here, we performed spatial transcriptomics and proteomics of progressive MS brain tissue to delineate this complexity and to translate our findings into therapeutic targets aimed at rescuing dying neurons. We discovered micro-areas of structurally intact cortex, which exhibited reduced neuronal pro-survival signals within an imbalanced pro- and anti-inflammatory milieu, unmasking new therapeutic possibilities to prevent further decline. Spatially resolved ligand–receptor interactome analysis identified targetable intercellular interactions including G-protein coupled receptor GRP37L1 and growth factor receptors, such as FGFR3, which are central to the survival of CNS cells, in prticular neurons. These findings place progressive MS in a new light and provide promising opportunities to overcome neurodegeneration.
HostingRepository	PRIDE
AnnounceDate	2022-06-06
AnnouncementXML	Submission_2022-06-05_20:38:43.995.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabian Coscia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-07 02:46:42	ID requested
⏵ 1	2022-06-05 20:38:44	announced

Dataset with its publication pending

submitter keyword: Multiple Sclerosis Spatial Proteomics

Lars Fugger
contact affiliation	University of Oxford
contact email	lars.fugger@ndcn.ox.ac.uk
lab head
Fabian Coscia
contact affiliation	University of Copenhagen NNF Center for Protein Research
contact email	fabian.coscia@cpr.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD026529

PRIDE project URI

• PRIDE
  1. PXD026529
     1. Label: PRIDE project
     2. Name: Spatial multiomics identifies CNS drug targets for progressive multiple sclerosis