PXD026463

PXD026463 is an original dataset announced via ProteomeXchange.

Title	Iimmunopeptidomics pipeline for generation of personalized oncolytic cancer vaccines.
Description	We used a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumour cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. We used MHC-I immunoaffinity purification in a murine colon tumor model from CT26 cells. The selection of the target candidates was then based on two separate approaches: RNAseq analysis and HEX software.
HostingRepository	PRIDE
AnnounceDate	2022-04-06
AnnouncementXML	Submission_2022-04-06_09:29:24.227.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Branca
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-03 06:40:04	ID requested
⏵ 1	2022-04-06 09:29:25	announced

Feola S, Chiaro J, Martins B, Russo S, Fusciello M, Yl, ö, sm, ä, ki E, Bonini C, Ruggiero E, Hamdan F, Feodoroff M, Antignani G, Viitala T, Pesonen S, Gr, ö, nholm M, Branca RMM, Lehti, ö J, Cerullo V, A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines. Elife, 11():(2022) [pubmed]

submitter keyword: mouse, murine, colon cancer, CT26, immunopeptidome, ligandome, oncolytic virus, cancer vaccines, personalized cancer vaccines

Janne Lehtiö
contact affiliation	Dep. of Oncology-Pathology, Karolinska Institutet, Scilifelab, Stockholm, Sweden
contact email	janne.lehtio@ki.se
lab head
Rui Branca
contact affiliation	Clinical Proteomics Unit, Dep. of Oncology-Pathology
contact email	rui.mamede-branca@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD026463

PRIDE project URI

• PRIDE
  1. PXD026463
     1. Label: PRIDE project
     2. Name: Iimmunopeptidomics pipeline for generation of personalized oncolytic cancer vaccines.