PXD026461 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training in mouse skeletal muscle |
Description | Timed physical activity might potentiate the health benefits of training. The underlying signaling events triggered by exercise at different times of the day are, however, poorly understood. Here, we found that time-dependent variations in maximal treadmill exercise capacity of naïve mice were associated with energy stores, mostly hepatic glycogen levels. Importantly, running at different times of the day resulted in a vastly different activation of signaling pathways, e.g., related to stress response, vesicular trafficking, repair, and regeneration. Second, voluntary wheel running at the opposite phase of the dark, feeding period surprisingly revealed minimal Zeitgeber (i.e., synchronizing) activity of training. This integrated study provides important insights into the circadian regulation of endurance performance and the control of the circadian clock by exercise. In future studies, these results could contribute to better understand circadian aspects of training design in athletes and the application of chrono-exercise-based interventions in patients. |
HostingRepository | PRIDE |
AnnounceDate | 2021-06-22 |
AnnouncementXML | Submission_2021-06-21_21:41:53.383.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD026461 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Danilo Ritz |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos; Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-03 02:51:03 | ID requested | |
⏵ 1 | 2021-06-21 21:41:54 | announced | |
Publication List
Maier G, Delezie J, Westermark PO, Santos G, Ritz D, Handschin C, Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle. J Physiol, 600(4):769-796(2022) [pubmed] |
Keyword List
submitter keyword: exercise |
skeletal muscle |
transcriptomics |
proteomics |
metabolism |
energy homeostasis |
circadian clock |
Zeitgeber |
Contact List
alexander schmidt |
contact affiliation | Dr. Alexander Schmidt Proteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland |
contact email | alex.schmidt@unibas.ch |
lab head | |
Danilo Ritz |
contact affiliation | Proteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland |
contact email | danilo.ritz@unibas.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026461
- Label: PRIDE project
- Name: Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training in mouse skeletal muscle