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PXD026461

PXD026461 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTranscriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training in mouse skeletal muscle
DescriptionTimed physical activity might potentiate the health benefits of training. The underlying signaling events triggered by exercise at different times of the day are, however, poorly understood. Here, we found that time-dependent variations in maximal treadmill exercise capacity of naïve mice were associated with energy stores, mostly hepatic glycogen levels. Importantly, running at different times of the day resulted in a vastly different activation of signaling pathways, e.g., related to stress response, vesicular trafficking, repair, and regeneration. Second, voluntary wheel running at the opposite phase of the dark, feeding period surprisingly revealed minimal Zeitgeber (i.e., synchronizing) activity of training. This integrated study provides important insights into the circadian regulation of endurance performance and the control of the circadian clock by exercise. In future studies, these results could contribute to better understand circadian aspects of training design in athletes and the application of chrono-exercise-based interventions in patients.
HostingRepositoryPRIDE
AnnounceDate2021-06-22
AnnouncementXMLSubmission_2021-06-21_21:41:53.383.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD026461
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDanilo Ritz
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos; Q Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-03 02:51:03ID requested
12021-06-21 21:41:54announced
Publication List
Maier G, Delezie J, Westermark PO, Santos G, Ritz D, Handschin C, Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle. J Physiol, 600(4):769-796(2022) [pubmed]
Keyword List
submitter keyword: exercise
skeletal muscle
transcriptomics
proteomics
metabolism
energy homeostasis
circadian clock
Zeitgeber
Contact List
alexander schmidt
contact affiliationDr. Alexander Schmidt Proteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland
contact emailalex.schmidt@unibas.ch
lab head
Danilo Ritz
contact affiliationProteomics Core Facility Biozentrum, University of Basel Klingelbergstrasse 50/70 CH-4056 Basel / Switzerland
contact emaildanilo.ritz@unibas.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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