PXD026454 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deep proteomic and phosphoproteomic profiling of neuroblastoma treated with XPO1 inhibitor Selinexor |
Description | Neuroblastoma accounts for 15% of cancer-related deaths in children, highlighting an unmet need for novel therapies. Selinexor is a small molecule inhibitor of XPO1 that shuffles cargo proteins with a nuclear export sequence, many of which are essential for cancer growth and cell maintenance, from the nucleus to the cytosol. We systematically tested the effect of selinexor against neuroblastoma cells in vitro and in vivo and used a proteomics screening approach to interrogate unknown mechanisms of action. We found that selinexor induces its cytotoxic effects in neuroblastoma through the nuclear accumulation of p53. By combining selinexor with an aurora kinase inhibitor, alisertib that is already in clinical use for neuroblastoma, we show that p53-mediated lethality can be further augmented supporting clinical testing of this drug combination against neuroblastoma |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:39:04.452.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hong Wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-03 02:44:03 | ID requested | |
1 | 2023-03-11 00:10:30 | announced | |
⏵ 2 | 2023-11-14 08:39:09 | announced | 2023-11-14: Updated project metadata. |
Publication List
Nguyen R, Wang H, Sun M, Lee DG, Peng J, Thiele CJ, Combining selinexor with alisertib to target the p53 pathway in neuroblastoma. Neoplasia, 26():100776(2022) [pubmed] |
Keyword List
submitter keyword: TMTpro, phosphoproteome, Selinexor, XPO1,Neuroblastoma, proteome |
Contact List
Hong Wang |
contact affiliation | St.Jude Children's Research Hospital |
contact email | Hong.Wang@stjude.org |
lab head | |
Hong Wang |
contact affiliation | St.Jude children's Research hospi |
contact email | hong.wang@stjude.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026454 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026454
- Label: PRIDE project
- Name: Deep proteomic and phosphoproteomic profiling of neuroblastoma treated with XPO1 inhibitor Selinexor