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PXD026442

PXD026442 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19
DescriptionWe present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of variation of immune response proteins during COVID-19 infection. The immune response is activated in asymptomatic infection, but is dysregulated in mild and severe COVID-19 patients. Our data suggest that the turning point depends on the function of myeloid cells and neutrophils. In addition, immune defects persist into the recovery stage, until 12 months after diagnosis. Moreover, disorders of cholesterol metabolism span the entire progression of the disease, starting from asymptomatic infection and lasting to recovery. Our data suggest that prolonged dysregulation of the immune response and cholesterol metabolism might be the pivotal causative agent of long-lasting disorders in blood coagulation and cardiopathy. Our study provides a comprehensive understanding of COVID-19 pathogenesis, which is instructive for the development of early intervention strategies to ameliorate complex disease sequelae.
HostingRepositoryiProX
AnnounceDate2021-06-03
AnnouncementXMLSubmission_2023-02-05_19:33:43.704.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmittershuaixin Gao
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrumenttime-of-flight
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-03 01:32:14ID requested
12021-08-31 02:53:08announced
22023-02-05 19:33:44announced2023-02-06: Update publication information.
Publication List
Chen Y, Zhang N, Zhang J, Guo J, Dong S, Sun H, Gao S, Zhou T, Li M, Liu X, Guo Y, Ye B, Zhao Y, Yu T, Zhan J, Jiang Y, Wong CCL, Gao GF, Liu WJ, Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochim Biophys Acta Proteins Proteom, 1870(2):140736(2022) [pubmed]
Keyword List
submitter keyword: asymptomatic, symptomatic, convalescent periods, COVID-19
Contact List
Catherine CL Wong
contact affiliationCenter for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact emailcatherine_wong@bjmu.edu.cn
lab head
shuaixin Gao
contact affiliationCenter for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact emailgaoshuaixin@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI