PXD026442

PXD026442 is an original dataset announced via ProteomeXchange.

Title	Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19
Description	We present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of variation of immune response proteins during COVID-19 infection. The immune response is activated in asymptomatic infection, but is dysregulated in mild and severe COVID-19 patients. Our data suggest that the turning point depends on the function of myeloid cells and neutrophils. In addition, immune defects persist into the recovery stage, until 12 months after diagnosis. Moreover, disorders of cholesterol metabolism span the entire progression of the disease, starting from asymptomatic infection and lasting to recovery. Our data suggest that prolonged dysregulation of the immune response and cholesterol metabolism might be the pivotal causative agent of long-lasting disorders in blood coagulation and cardiopathy. Our study provides a comprehensive understanding of COVID-19 pathogenesis, which is instructive for the development of early intervention strategies to ameliorate complex disease sequelae.
HostingRepository	iProX
AnnounceDate	2021-06-03
AnnouncementXML	Submission_2023-02-05_19:33:43.704.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	shuaixin Gao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	time-of-flight

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-03 01:32:14	ID requested
1	2021-08-31 02:53:08	announced
⏵ 2	2023-02-05 19:33:44	announced	2023-02-06: Update publication information.

Chen Y, Zhang N, Zhang J, Guo J, Dong S, Sun H, Gao S, Zhou T, Li M, Liu X, Guo Y, Ye B, Zhao Y, Yu T, Zhan J, Jiang Y, Wong CCL, Gao GF, Liu WJ, Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochim Biophys Acta Proteins Proteom, 1870(2):140736(2022) [pubmed]

submitter keyword: asymptomatic, symptomatic, convalescent periods, COVID-19

Catherine CL Wong
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	catherine_wong@bjmu.edu.cn
lab head
shuaixin Gao
contact affiliation	Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University
contact email	gaoshuaixin@126.com
dataset submitter

iProX dataset URI