PXD026411

PXD026411 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteome for C.elegans by 3plex mTRAQ
Description	Vesicle-mediated transport is a fundamental part of the secretory and endocytic pathways. In addition to their role in membrane protein trafficking, Arf-like protein subfamily of small GTPases also plays an important role in development, maintenance of Golgi structure and function. Proper protein trafficking is critical for cellular integrity and studies demonstrate that aberrant protein sorting leads to various diseases in many organisms including humans. However, to date, there is no report showing the role of Golgi apparatus and Golgi proteins in organismal longevity. Organisms dynamically reprogram their transcriptome and proteome as a response to internal and external changes, which alter physiological processes including aging. Compared to many transcriptomic studies that identified aging-regulatory genes, proteomic studies that identified aging-regulatory proteins are relatively scarce. By using a quantitative proteomic approach, we identified MON-2, an Arf-Gef protein implicated in Golgi-to-endosome trafficking, as a longevity-promoting protein. We found that MON-2 is essential for the long lifespan of various longevity mutants. Our results demonstrate that Golgi-to-endosome trafficking is an integral part of lifespan regulation.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:26:49.003.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shinyeong Ju
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-01 22:08:26	ID requested
⏵ 1	2022-02-17 04:26:49	announced

Jung Y, Artan M, Kim N, Yeom J, Hwang AB, Jeong DE, Altintas Ö, Seo K, Seo M, Lee D, Hwang W, Lee Y, Sohn J, Kim EJE, Ju S, Han SK, Nam HJ, Adams L, Ryu Y, Moon DJ, Kang C, Yoo JY, Park SK, Ha CM, Hansen M, Kim S, Lee C, Park SY, Lee SV, . Sci Adv, 7(49):eabj8156(2021) [pubmed]

submitter keyword: C. elegans, mTRAQ, LC-MS/MS

Cheolju Lee
contact affiliation	Center for Theragnosis, Korea Institute of Science and Technology, Republic of Korea
contact email	clee270@kist.re.kr
lab head
Shinyeong Ju
contact affiliation	KIST
contact email	syju@kist.re.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026411

PRIDE project URI

• PRIDE
  1. PXD026411
     1. Label: PRIDE project
     2. Name: Quantitative proteome for C.elegans by 3plex mTRAQ