PXD026408 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | RADIATION-INDUCED MODIFICATIONS IN MICRO-RNA AND PROTEOMIC CARGO IN PLASMA-DERIVED EXTRACELLULAR VESICLES |
Description | In this study, to delineate the radiation-induced changes in miRNAs and protein cargo, we established the microRNA and proteome profiles of plasma EVs collected from mice that had been sham- (SI), whole body (WBI), or partial body irradiated (PBI) with 2 Gy X-rays 24 hours before. The radiation-induced changes in the miRNA and protein composition of EVs can influence the stress response of distant cells by propagating damaging or protective signals. Testing EVs in functional assays may be a read out of the multiple radiation-induced signaling networks, crucial for gaining an understanding of the EVs properties. Therefore, to functionally elucidate the pathophysiological changes in the contents of EVs induced by irradiation, we here investigated the EV-induced cellular responses in vivo, by injecting WBI, PBI and SI plasma-derived EVs in the cerebellum of neonatal mice, highly susceptible to radiation injury, and evaluating the level of apoptosis. |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-10 |
AnnouncementXML | Submission_2022-03-10_01:45:33.386.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Christine von Toerne |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-01 21:59:13 | ID requested | |
⏵ 1 | 2022-03-10 01:45:33 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: MiRNome, proteomics, radiation |
ionizing radiation |
neonatal cerebellum |
apoptosis |
Contact List
Maria Teresa Mancuso |
contact affiliation | Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy |
contact email | mariateresa.mancuso@enea.it |
lab head | |
Christine von Toerne |
contact affiliation | Helmholtz Zentrum München |
contact email | vontoerne@helmholtz-muenchen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD026408 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026408
- Label: PRIDE project
- Name: RADIATION-INDUCED MODIFICATIONS IN MICRO-RNA AND PROTEOMIC CARGO IN PLASMA-DERIVED EXTRACELLULAR VESICLES