⮝ Full datasets listing

PXD026408

PXD026408 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRADIATION-INDUCED MODIFICATIONS IN MICRO-RNA AND PROTEOMIC CARGO IN PLASMA-DERIVED EXTRACELLULAR VESICLES
DescriptionIn this study, to delineate the radiation-induced changes in miRNAs and protein cargo, we established the microRNA and proteome profiles of plasma EVs collected from mice that had been sham- (SI), whole body (WBI), or partial body irradiated (PBI) with 2 Gy X-rays 24 hours before. The radiation-induced changes in the miRNA and protein composition of EVs can influence the stress response of distant cells by propagating damaging or protective signals. Testing EVs in functional assays may be a read out of the multiple radiation-induced signaling networks, crucial for gaining an understanding of the EVs properties. Therefore, to functionally elucidate the pathophysiological changes in the contents of EVs induced by irradiation, we here investigated the EV-induced cellular responses in vivo, by injecting WBI, PBI and SI plasma-derived EVs in the cerebellum of neonatal mice, highly susceptible to radiation injury, and evaluating the level of apoptosis.
HostingRepositoryPRIDE
AnnounceDate2022-03-10
AnnouncementXMLSubmission_2022-03-10_01:45:33.386.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristine von Toerne
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-01 21:59:13ID requested
12022-03-10 01:45:33announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: MiRNome, proteomics, radiation
ionizing radiation
neonatal cerebellum
apoptosis
Contact List
Maria Teresa Mancuso
contact affiliationLaboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy
contact emailmariateresa.mancuso@enea.it
lab head
Christine von Toerne
contact affiliationHelmholtz Zentrum München
contact emailvontoerne@helmholtz-muenchen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD026408
PRIDE project URI
Repository Record List
[ + ]