PXD026380

PXD026380 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Estrogen Mediated Enhancement of MSC-Induced Angiogenesis in vivo
Description	Therapeutic use of mesangial stem cells (MSCs) for tissue repair, including heart, has great potential. MSCs from multiple sources, including those derived from human umbilical matrix, namely Wharton's jelly, may serve as a resourceful candidate. Even after more than a decade, low engraftment efficacy of MSCs, in vivo, remains a limitation which requires in-depth understanding of the mechanisms and factors involved to facilitate a better and clinically relevant outcome. We recently hypothesized and demonstrated that the sex hormone – 17-beta estradiol (E2) – facilitates protective processes within the cardiovascular system by modulating MSC function, in vitro. Here, using a proteomic approach, we investigated the angiogenic potential of MSCs in vivo and the modulatory actions of E2 on mechanisms involved in tissue repair (potentially post-ischemic injury). Employing an in vivo approach with an ovariectomized (OVX) mice model, we evaluated the effects of E2 on MSC-induced angiogenesis using Matrigel plug assay.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_04:28:09.492.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026380
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Felicia Antohe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-31 07:14:50	ID requested
⏵ 1	2022-02-17 04:28:10	announced

Mihai MC, Popa MA, Ș, uic, ă VI, Antohe F, Jackson EK, Leeners B, Simionescu M, Dubey RK, Proteomic Analysis of Estrogen-Mediated Enhancement of Mesenchymal Stem Cell-Induced Angiogenesis In Vivo. Cells, 10(9):(2021) [pubmed]

submitter keyword: MSC, angiogeneis, proteomics

Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology
contact email	felicia.antohe@icbp.ro
lab head
Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology "N. Simionescu"
contact email	felicia.antohe@icbp.ro
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026380

PRIDE project URI

• PRIDE
  1. PXD026380
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Estrogen Mediated Enhancement of MSC-Induced Angiogenesis in vivo