PXD026371

PXD026371 is an original dataset announced via ProteomeXchange.

Title	Exocrine and connective tissue signatures in early pancreatic adenocarcinoma foci and their surrounding tissue
Description	This project is reporting on microdissection proteomics of human operable, non-neoadjuvant treated pancreatic ductal adenocarcinomas (PDAC) with deep coverage of histologically neoplastic and adjacent healthier exocrine glands as well as stromal regions surrounding both. Through proteomic analysis, the parenchymal sample types differed significantly, with the malignant regions characterized by a broad downregulation of digestive enzymes. Instead, the stromal areas were alike, dominated by extracellular matrix proteins and lower expression of most metabolic pathways compared to the exocrine areas. Cholesterol synthesizing enzymes were more abundant in the tumor than stroma, as confirmed by an independent PDAC dataset and immunohistochemistry of PDAC microarrays. However, this was not accompanied by intratumor lipid deposition. Pathways most prognostic for survival were unexpectedly enriched in the histologically healthier exocrine glands, with a specific prognostic marker. Systematic analysis of pancreatic cancer transcriptomes from The Cancer Genome Atlas revealed that increased transcriptional complexity confers poor prognosis in PDAC.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:52:26.739.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yonghyo Kim
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-31 06:59:08	ID requested
1	2022-09-04 20:13:04	announced
⏵ 2	2023-11-14 08:52:27	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: lipid storage, lipid metabolism, exocrine,Pancreas, neoplastic region, parenchyma region, pancreatic cancer, stromal region

György Marko-Varga
contact affiliation	Division of Clinical Protein Science & Imaging, Department of Clinical Sciences (Lund), Department of Biomedical Engineering, Lund University, Lund, Sweden
contact email	gyorgymarkovarga@hotmail.com
lab head
Yonghyo Kim
contact affiliation	Lund University, Faculty of Medicine
contact email	duk0295@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD026371

PRIDE project URI

• PRIDE
  1. PXD026371
     1. Label: PRIDE project
     2. Name: Exocrine and connective tissue signatures in early pancreatic adenocarcinoma foci and their surrounding tissue