PXD026222 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic profiling of young and old mice in the bleomycin model |
Description | The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main differences is the juvenile age of animals that are usually used in experiments, resembling humans of around 20 years. Because IPF patients are usually older than 60 years, aging appears to play an important role in the pathogenesis of lung fibrosis. We here compared young (3 months) and old (21 months) mice 21 days after intratracheal bleomycin instillation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-10 |
AnnouncementXML | Submission_2024-09-10_00:19:10.061.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Daniel Veyel |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-05-24 03:47:50 | ID requested | |
⏵ 1 | 2024-09-10 00:19:10 | announced | |
Publication List
Klee S, Picart-Armada S, Wenger K, Birk G, Quast K, Veyel D, Rist W, Violet C, Luippold A, Haslinger C, Thomas M, Fernandez-Albert F, K, รค, stle M, Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity. Am J Physiol Lung Cell Mol Physiol, 324(3):L245-L258(2023) [pubmed] |
10.1152/ajplung.00253.2021; |
Keyword List
submitter keyword: Bleomycin, idiopathic pulmonary fibrosis, TMT, Fusion Lumos, LC-MS, lung, SPS MS3,C57BL/6J mouse |
Contact List
Wolfgang Rist |
contact affiliation | Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences |
contact email | wolfgang.rist@boehringer-ingelheim.com |
lab head | |
Daniel Veyel |
contact affiliation | Boehringer Ingelheim Pharma GmbH & Co. KG |
contact email | daniel.veyel@boehringer-ingelheim.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD026222 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026222
- Label: PRIDE project
- Name: Proteomic profiling of young and old mice in the bleomycin model