PXD026214

PXD026214 is an original dataset announced via ProteomeXchange.

Title	Consequences of sEH deletion in the polyoma middle T (PyMT) breast cancer tumor proteome
Description	The aim of this investigation was to study the consequences of interfering with soluble epoxide hydrolase (sEH) expression on tumor growth and metastasis in genetically modified animals that spontaneously generate tumors without the exogenous application of high concentrations of epoxide mediators or inhibitors. Therefore, breast cancer development was studied in mice expressing the polyoma middle T oncogene (PyMT) under the control of the mouse mammary tumor virus promoter, to induce spontaneous mammary tumors. To facilitate the study of endogenous sEH activity in tumor growth, PyMT mice were then crossed with sEH-/- mice to generate sEH-deficient mice that spontaneously generate breast tumors (so called PyMTsEH mice). For these analyses, primary tumors were removed from 20 week old mice.
HostingRepository	PRIDE
AnnounceDate	2021-09-14
AnnouncementXML	Submission_2021-09-21_22:09:43.733.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-24 03:46:39	ID requested
1	2021-09-14 06:30:07	announced
⏵ 2	2021-09-21 22:09:44	announced	2021-09-22: Updated publication reference for PubMed record(s): 34281173.

Kesavan R, Fr, ö, mel T, Zukunft S, Br, ü, ne B, Weigert A, Wittig I, Popp R, Fleming I, The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer. Int J Mol Sci, 22(13):(2021) [pubmed]

submitter keyword: LC-MSMS, Lymphangiogenesis, breast cancer, metastasis, macrophage

Ingrid Fleming
contact affiliation	Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-Universität, Frankfurt am Main, Germany
contact email	fleming@vrc.uni-frankfurt.de
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026214
     1. Label: PRIDE project
     2. Name: Consequences of sEH deletion in the polyoma middle T (PyMT) breast cancer tumor proteome