PXD026121

PXD026121 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Multi-omics characterization of recurrent exertional rhabdomyolysis in Standardbred horses
Description	During an episode of acute rhabdomyolysis, a microarray study identified differential expression of calcium-regulatory, mitochondrial and metabolic genes in gluteal muscle of Standardbreds. Whether this represents expression related to acute myodegeneration or a specific molecular signature of susceptibility to recurrent exertional rhabdomyolysis (RER) is currently unknown. We compared gluteal muscle histopathology, gene/protein expression and antioxidant concentrations between Standardbreds with a history of, but not currently experiencing rhabdomyolysis, and race-trained controls to derive a molecular susceptibility profile.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:37:37.639.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026121
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Stephanie Valberg
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-20 07:18:15	ID requested
1	2023-03-10 23:07:01	announced
⏵ 2	2023-11-14 08:37:38	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD026121;
Valberg SJ, Velez-Irizarry D, Williams ZJ, Henry ML, Iglewski H, Herrick K, Fenger C, Enriched Pathways of Calcium Regulation, Cellular/Oxidative Stress, Inflammation, and Cell Proliferation Characterize Gluteal Muscle of Standardbred Horses between Episodes of Recurrent Exertional Rhabdomyolysis. Genes (Basel), 13(10):(2022) [pubmed]

10.6019/PXD026121;

Valberg SJ, Velez-Irizarry D, Williams ZJ, Henry ML, Iglewski H, Herrick K, Fenger C, Enriched Pathways of Calcium Regulation, Cellular/Oxidative Stress, Inflammation, and Cell Proliferation Characterize Gluteal Muscle of Standardbred Horses between Episodes of Recurrent Exertional Rhabdomyolysis. Genes (Basel), 13(10):(2022) [pubmed]

Keyword List

ProteomeXchange project tag: Skeletal Muscle Proteome (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: muscle disease, myopathy, tying-up,equine

ProteomeXchange project tag: Skeletal Muscle Proteome (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: muscle disease, myopathy, tying-up,equine

Contact List

Stephanie Valberg
contact affiliation	Equine Neuromuscular Diagnostic Laboratory; Mary Anne McPhail Equine Performance Center; Large Animal Clinical Sciences; Michigan State University College of Veterinary Medicine
contact email	valbergs@msu.edu
lab head
Stephanie Valberg
contact affiliation	Michigan State University
contact email	valbergs@msu.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026121
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026121

PRIDE project URI

Repository Record List

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