PXD026116

PXD026116 is an original dataset announced via ProteomeXchange.

Title	Rintatolimod induces antiviral activities in human pancreatic cancer cells: opening for an anti-COVID-19 opportunity in cancer patients?
Description	Severe acute respiratory virus-2 (SARS-CoV2) has spread globally leading to a devastating loss of life. Large registry studies have begun to shed light on the epidemiological and clinical vulnerabilities of cancer patients who succumb to or endure poor outcomes of SARS-CoV-2. Specific treatment for COVID-19 infections in cancer patients is lacking while the demand for treatment is increasing. Therefore, we explored the effect of Rintatolimod (Ampligen), a Toll-like receptor 3 (TLR3) agonist, to treat uninfected human pancreatic cancer cells (HPACs). The direct effect of Rintatolimod was measured by targeted gene expression profiling and by proteomics measurements. Our results showed that Rintatolimod induces an antiviral effect in HPACs by inducing RNase L- dependent and independent pathways of the innate immune system. Treatment with Rintatolimod activated the interferon signaling pathway, leading to the overexpression of several cytokines and chemokines in epithelial cells. Furthermore, Rintatolimod treatment increased the expression of angiogenesis-related genes without promoting fibrosis, which is the main cause of death in COVID-19 infected patients. We conclude that Rintatolimod could be considered an early additional treatment option for cancer patients who are infected with SARS-CoV-2 to prevent the complicated severity of the disease.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_08:53:47.743.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026116
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lona Zeneyedpour
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-20 03:31:21	ID requested
⏵ 1	2022-02-17 08:53:48	announced

Mustafa DAM, Saida L, Latifi D, Wismans LV, de Koning W, Zeneyedpour L, Luider TM, van den Hoogen B, van Eijck CHJ, Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients? Cancers (Basel), 13(12):(2021) [pubmed]

ProteomeXchange project tag: Covid-19

submitter keyword: human, Covid-19

Dana Adel Mustafa
contact affiliation	Pathology department, The tumor immuno-pathology lab, Erasmus medical center, the netherlands
contact email	d.mustafa@erasmusmc.nl
lab head
Lona Zeneyedpour
contact affiliation	Erasmus medical center
contact email	l.zeneyedpour@erasmusmc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD026116

PRIDE project URI

• PRIDE
  1. PXD026116
     1. Label: PRIDE project
     2. Name: Rintatolimod induces antiviral activities in human pancreatic cancer cells: opening for an anti-COVID-19 opportunity in cancer patients?