PXD026115

PXD026115 is an original dataset announced via ProteomeXchange.

Title	Protein changes in the infarct region of ischemia/reperfused rat hearts revealed by spatialOMx
Description	Myocardial infarction (MI) is the most common cause of death worldwide. Timely diagnosis and early restoration of the blood flow prevents further tissue damage. However, this sudden reperfusion can also lead to so-called ischemia/reperfusion (I/R) injury. Although the different pathological processes activated in I/R injury, like cell death and inflammation have been previously addressed, the exact pathophysiological mechanisms remain unclear. For the development of strategies that minimize myocardial damage a better understanding of the underlying alterations in protein and signaling pathways is required. In this study we aim to identify the protein signature of cardiac I/R injury, therefore we use a spatialOMx approach, combining protein mass spectrometry imaging (MSI) and a classical label-free proteomics workflow on the same tissue section, to further address the observed alterations
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:39:22.480.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephanie Mezger
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-20 01:57:02	ID requested
1	2023-03-11 00:19:28	announced
⏵ 2	2023-11-14 08:39:23	announced	2023-11-14: Updated project metadata.

Mezger STP, Mingels AMA, Souli, é M, Peutz-Kootstra CJ, Bekers O, Mulder P, Heeren RMA, Cillero-Pastor B, Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics. Int J Mol Sci, 23(22):(2022) [pubmed]

submitter keyword: proteomics, protein, ischemia-reperfusion, rat heart, LMD, MALDI-MSI,spatialOMx

Berta Cillero-Pastor
contact affiliation	Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, Maastricht, The Netherlands
contact email	b.cilleropastor@maastrichtuniversity.nl
lab head
Stephanie Mezger
contact affiliation	Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, The Netherlands
contact email	s.mezger@maastrichtuniversity.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD026115

PRIDE project URI

• PRIDE
  1. PXD026115
     1. Label: PRIDE project
     2. Name: Protein changes in the infarct region of ischemia/reperfused rat hearts revealed by spatialOMx