PXD026084
PXD026084 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | New insights into the regulatory role of the type II antitoxin HigA in Pseudomonas aeruginosa virulence |
| Description | Bacterial type II toxin-antitoxin (TA) systems are abundant genetic elements and involved in a diverse array of physiological processes. They encode a protein antitoxin protein that directly binds and effectively neutralizes the protein toxin. Latest studies have highlighted key roles of the type II TA modules in bacterial virulence and pathogenesis but the underlying mechanisms remains elusive. In this study, we investigated the repression function of antitoxin HigA in Pseudomonas aeruginosa infection. Proteomic analysis of the higA deletion strain revealed enhanced expression levels of proteins contributing to pathogenicity. We further verified that HigA negatively controlled T3SS and T6SS expression by directly interacting with the promoter regions of the respective regulators amrZ and exsA. In that sense, relief of HigA-mediated transcriptional inhibition upon stress stimulation could induce virulence genes. These findings reinforce the crucial roles of type II antitoxin in bacterial infection, which highlights the potential of HigBATA system as a target for antibacterial treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2021-05-14 |
| AnnouncementXML | Submission_2021-05-19_00:34:34.227.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yingjie Song |
| SpeciesList | scientific name: Pseudomonas aeruginosa PA14; NCBI TaxID: 652611; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-05-19 00:34:07 | ID requested | |
| ⏵ 1 | 2021-05-19 00:34:34 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Type II toxin-antitoxin systems, Pseudomonas aeruginosa, gene regulation, type III secretion system and type VI secretion system, pathogenesis |
Contact List
| Yongxing He | |
|---|---|
| contact affiliation | LanZhou University |
| contact email | heyx@lzu.edu.cn |
| lab head | |
| Yingjie Song | |
| contact affiliation | SiChuan University |
| contact email | 1127551970@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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