PXD026016

PXD026016 is an original dataset announced via ProteomeXchange.

Title	Design and development of nanoproteomics strategies for biomarker identification in cerebrospinal fluid of leptomeningeal disease, using as model lymphoma non-Hodgkin B.
Description	The early diagnosis of leptomeningeal disease is a challenge because it is an asymptomatic pathology in the early stages. Hence, it is highly relevant to identify a panel of biomarkers to help in the diagnosis and/or prognostic. For this purpose, we have explored a multipronged proteomics approaches, in cerebrospinal fluid, to determine a potential panel of biomarkers in cerebrospinal fluid. Thus, a systematic and exhaustive characterization of more than 347 CSF samples have been performed by an integrated LC-MS/MS (n 20) and functional proteomics (n 347) analysis to establish protein profiles which has been useful to develop a panel of biomarkers validated by in silico approaches.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_03:54:29.497.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD026016
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Pablo Juanes-Velasco
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-14 02:44:48	ID requested
⏵ 1	2022-02-17 03:54:30	announced

Juanes-Velasco P, Galicia N, Pin E, Jara-Acevedo R, Carabias-S, á, nchez J, Garc, í, a-Valiente R, Lecrevisse Q, Pedreira CE, Gongora R, Sanchez-Santos JM, Lorenzo-Gil H, Landeira-Vi, ñ, uela A, Bareke H, Orfao A, Nilsson P, Fuentes M, Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid. Cancers (Basel), 14(2):(2022) [pubmed]

submitter keyword: Cerebrospinal Fluid (CSF), Leptomeningeal Metastasis (LM), LC-MS/MS, Protein microarrays, Protein-based biomarker.

Manuel Fuentes García
contact affiliation	Department of Medicine and General Service of Cytometry, Cancer Research Centre-IBMCC, IBSAL. University of Salamanca-CSIC
contact email	mfuentes@usal.es
lab head
Pablo Juanes-Velasco
contact affiliation	Department of Medicine and General Service of Cytometry, Cancer Research Centre, IBSAL. University of Salamanca-CSIC, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain
contact email	pablojuanesvelasco@usal.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026016
     1. Label: PRIDE project
     2. Name: Design and development of nanoproteomics strategies for biomarker identification in cerebrospinal fluid of leptomeningeal disease, using as model lymphoma non-Hodgkin B.