PXD026010

PXD026010 is an original dataset announced via ProteomeXchange.

Title	Acetylome Profiling Reveals the Endogenous Substrates of HDAC6
Description	HDAC6 inhibitors are novel targeted therapies showing good clinical response in a variety of different malignancies. However, their use and farther development is hampered by the limited knowledge regarding what are the endogenous substrates of HDAC6 enzyme. Here we plan to complete acetylome profiling of HAP1 cells with and without HDAC6 knockout to identify which are the HDAC6 substrates and what are the differences between the wildtype and HDAC6-KO cells.
HostingRepository	PRIDE
AnnounceDate	2024-04-02
AnnouncementXML	Submission_2024-04-02_06:41:58.313.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuxin Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dihydroxylated residue; acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-14 02:44:15	ID requested
1	2022-11-09 03:25:37	announced
⏵ 2	2024-04-02 06:41:59	announced	2024-04-02: Updated project metadata.

10.1038/s43018-022-00489-5;

Zeleke TZ, Pan Q, Chiuzan C, Onishi M, Li Y, Tan H, Alvarez MJ, Honan E, Yang M, Chia PL, Mukhopadhyay P, Kelly S, Wu R, Fenn K, Trivedi MS, Accordino M, Crew KD, Hershman DL, Maurer M, Jones S, High A, Peng J, Califano A, Kalinsky K, Yu J, Silva J, Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer. Nat Cancer, 4(2):257-275(2023) [pubmed]

submitter keyword: Mass Spectrometry, HAP1 Cell, Acetylome,Proteomics

Junmin Peng
contact affiliation	St. Jude Children’s Research Hospital
contact email	junmin.peng@stjude.org
lab head
Yuxin Li
contact affiliation	St. Jude Children's Research Hospital
contact email	yuxin.li@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD026010

PRIDE project URI

• PRIDE
  1. PXD026010
     1. Label: PRIDE project
     2. Name: Acetylome Profiling Reveals the Endogenous Substrates of HDAC6