PXD025990

PXD025990 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	An ultrasensitive method for analysis of viral spike N-glycoforms
Description	Viruses can evade the host immune system by displaying numerous glycans on their surface "spike-proteins" that cover immune epitopes. We have developed an ultrasensitive "single pot" method to assess glycan occupancy and the extent of glycan processing from high-mannose to complex forms at each N-glycosylation site. Though aimed at characterizing glycosylation of viral spike proteins as potential vaccines, this method is applicable for analysis of site-specific glycosylation of any glycoprotein.
HostingRepository	MassIVE
AnnounceDate	2022-08-12
AnnouncementXML	Submission_2022-08-12_10:31:05.716.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sabyasachi Baboo
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: BG505 SOSIP.664 MD39; scientific name: BG505 SOSIP.664;
ModificationList	HexNAc; Delta:H(1)N(-1)18O(1); Oxidation; 2-pyrrolidone-5-carboxylic acid (Gln)
Instrument	Q Exactive HF-X; timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-12 20:28:21	ID requested
⏵ 1	2022-08-12 10:31:06	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Proteinase K, N-glycan, heterogeneity, HIV, BG505, Env, viral spike, endoglycosidase

submitter keyword: Proteinase K, N-glycan, heterogeneity, HIV, BG505, Env, viral spike, endoglycosidase

Contact List

John R. Yates III
contact affiliation	The Scripps Research Institute
contact email	jyates@scripps.edu
lab head
Sabyasachi Baboo
contact affiliation	The Scripps Research Institute, La Jolla, CA
contact email	sbaboo@scripps.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000087414/