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PXD025978

PXD025978 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAbsolute Proteome Analysis of Hippocampus, Cortex and Cerebellum in Aged and Young Mice Reveals Changes in Energy Metabolism
DescriptionAging is associated with a general decline of cognitive functions, and it is widely accepted that this decline results from changes in expression of proteins involved in regulation of synaptic plasticity. However, several lines of evidence has accumulated that impaired function of aged brain may be related to significant alterations in the energy metabolism. In the current study, we employed the label-free „Total protein approach” (TPA) method to focus on similarities and differences in energy metabolism proteomes of young (1 month-old) and aged (22 month-old) murine brains. We quantified over 7,000 proteins in each of three analyzed brain structures: hippocampus, cerebral cortex and cerebellum. To the best of our knowledge, this is the most extensive quantitative proteomic description of energy metabolism pathways during physiological aging of mice. The analysis demonstrates that aging does not affect significantly the abundance of total proteins in the studied brain structures, however, the levels of proteins constituting energy metabolism pathways differ significantly between young and aged mice.
HostingRepositoryPRIDE
AnnounceDate2022-02-17
AnnouncementXMLSubmission_2022-02-17_04:35:21.239.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJacek Wisniewski
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-12 05:49:00ID requested
12022-02-17 04:35:22announced
Publication List
Drulis-Fajdasz D, Gostomska-Pampuch K, Duda P, Wi, ś, niewski JR, Rakus D, Quantitative Proteomics Reveals Significant Differences between Mouse Brain Formations in Expression of Proteins Involved in Neuronal Plasticity during Aging. Cells, 10(8):(2021) [pubmed]
Keyword List
submitter keyword: Aging, Hippocampus, Cortex, Cerebellum, Metabolism
Contact List
Jacek R Wisniewski
contact affiliationMax-Planck-Institute of Biochemistry, Martinsried, DE
contact emailjwisniew@biochem.mpg.de
lab head
Jacek Wisniewski
contact affiliationProteomics
contact emailjwisniew@biochem.mpg.de
dataset submitter
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Dataset FTP location
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