PXD025973

PXD025973 is an original dataset announced via ProteomeXchange.

Title	Skin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Description	Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in enhanced ovary size, extended estrus days, and anti-Mullerian hormone (AMH) expression. It likewise enhances the sexual responsiveness and attractiveness of females and male-female interactions of both males and females. Conditional knockout of p53 specifically in skin keratinocytes abolished UV’s effects. In humans, UV exposure enhanced romantic passion in both genders increased testosterone levels in men. Our data, revealing that UVB triggers a skin-brain-gonadal axis through skin p53 activation, offers therapeutic opportunities for sex-steroid-related dysfunctions. We speculate that during human furless skin evolution, the skin became the front-line regulator of the response to UVB.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_03:27:56.001.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-12 01:46:34	ID requested
⏵ 1	2022-02-17 03:27:57	announced

Parikh R, Sorek E, Parikh S, Michael K, Bikovski L, Tshori S, Shefer G, Mingelgreen S, Zornitzki T, Knobler H, Chodick G, Mardamshina M, Boonman A, Kronfeld-Schor N, Bar-Joseph H, Ben-Yosef D, Amir H, Pavlovsky M, Matz H, Ben-Dov T, Golan T, Nizri E, Liber D, Liel Y, Brenner R, Gepner Y, Karnieli-Miller O, Hemi R, Shalgi R, Kimchi T, Percik R, Weller A, Levy C, Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior. Cell Rep, 36(8):109579(2021) [pubmed]

submitter keyword: UVB Light, Sexual Behavior, proteomics

Carmit Levy
contact affiliation	Department of Human Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel-Aviv, Israel 69978
contact email	carmitlevy@post.tau.ac.il
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD025973

PRIDE project URI

• PRIDE
  1. PXD025973
     1. Label: PRIDE project
     2. Name: Skin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior