PXD025968

PXD025968 is an original dataset announced via ProteomeXchange.

Title	Comparative analysis of serum proteins between hepatitis B virus genotype B and C infection DIA-based quantitative proteomics
Description	Hepatitis B virus (HBV) is an enveloped, coated, non-cytopathic and hepatotropic partially double-stranded DNA virus in the family Hepadnaviridae genus Orthohepadnavirus. Despite significant progress in the availability of safe vaccines and antiviral therapies against HBV, it still affects approximately 257 million people worldwide and is responsible for about 887,000 deaths per year around the world [4]. HBV infection, which are associated with acute and chronic liver failure responses to viruses attacked the liver, can result in inactive carrier state, chronic hepatitis, or fulminant hepatitis and put them at high risk to develop advanced liver fibrosis and cirrhosis, and even hepatocellular cancer. Many viral factors, which could affect the disparity of clinical outcomes or disease prognosis during chronic HBV infection, have been reported in previous studies; among them, the viral genotype, as well as HBV mutations ascribing the virus to a certain phenotype, was reported to be the most important factor influencing viral pathogenesis, including the change of host immune recognition, the enhanced virulence with increased HBV replication and the facilitation of cell attachment or penetration.
HostingRepository	PRIDE
AnnounceDate	2022-02-17
AnnouncementXML	Submission_2022-02-17_03:25:23.831.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dahai Wei
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dihydroxylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-12 01:46:03	ID requested
⏵ 1	2022-02-17 03:25:24	announced

Chen Y, Wei D, Deng M, Comparative Analysis of Serum Proteins Between Hepatitis B Virus Genotypes B and C Infection by DIA-Based Quantitative Proteomics. Infect Drug Resist, 14():4701-4715(2021) [pubmed]

submitter keyword: Serum proteins HBV genotype B and C infection DIA-based quantitative proteomics

Dahai Wei
contact affiliation	The Affiliated Hospital of Jiaxing University
contact email	wei_dahai@hotmail.com
lab head
Dahai Wei
contact affiliation	The Affiliated Hospital of Jiaxing University
contact email	wei_dahai@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025968
     1. Label: PRIDE project
     2. Name: Comparative analysis of serum proteins between hepatitis B virus genotype B and C infection DIA-based quantitative proteomics