PXD025957

PXD025957 is an original dataset announced via ProteomeXchange.

Title	Liver proteome upon in vivo N-acetylgalactosamine-conjugated antisense oligonucleotide silencing of ceramide synthase 2
Description	Mouse liver proteome was investigated upon in vivo mouse treatment with a N-acetylgalactosamine-conjugated antisense oligonucleotide engineered to silence ceramide synthase 2 specifically in hepatocytes in vivo. The data is a part of a study on the involvement of ceramide enzymatic machinery in cardiovasular disorders and its potential as a target for the disease treatment.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:18.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sergey Kovalchuk
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-05-11 23:37:26	ID requested
1	2023-05-10 13:16:43	announced
⏵ 2	2023-11-14 08:46:21	announced	2023-11-14: Updated project metadata.

Schmidt S, Gallego SF, Zelnik ID, Kovalchuk S, Alb, æ, k N, Sprenger RR, Ø, verup C, Pewzner-Jung Y, Futerman AH, Lindholm MW, Jensen ON, Ejsing CS, Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death. Mol Ther, 30(4):1661-1674(2022) [pubmed]

submitter keyword: silencing,Liver, mouse, proteome, ceramide synthase 2

Sergey Igorevich Kovalchuk
contact affiliation	Syddansk University, Odense, Denmark Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
contact email	xerx222@gmail.com
lab head
Sergey Kovalchuk
contact affiliation	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, RAS
contact email	xerx222@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD025957

PRIDE project URI

• PRIDE
  1. PXD025957
     1. Label: PRIDE project
     2. Name: Liver proteome upon in vivo N-acetylgalactosamine-conjugated antisense oligonucleotide silencing of ceramide synthase 2